Abstract: Objective To explore and analysis the effects of Gutongling tincture on serum 5-hydroxytryptamine (5-HT) and β-Endorphins(β-EP) leveles in the Lumbar disc herniation patients. Methods From April 2019 to January 2023, 120 cases of patients with lumbar disc herniation diagnosed and treated in Xinjiang Production and Construction Corps Hospital, Chengbei Branch were selected as the study subjects, and the 120 patients were divided into the Gutongling tincture group of 60 cases and the control group of 60 cases accorded to the 1:1 random drawing method. The control group were treated with conventional drugs, while the Gutongling tincture group were treated with Gutongling tincture on the basis of the control group's treatment. Continuous treatment observation were conducted for eight weeks in the two groups, and serum 5-HT and β-EP levels were detected in both groups of patients, observed the clinical efficacy, the changes of range of lumbar flexion and pain MPQ score. Results After eight weeks of treatment, the excellent and good efficacy rate of the Gutongling tincture group were significantly higher than the control group (P<0.05). The pain MPQ scores of both groups after eight weeks of treatment were significantly lower than before treatment (P<0.05), while the pain MPQ scores of the Gutongling tincture group after eight weeks of treatment were significantly lower than those of the control group (P<0.05). After eight weeks of treatment, the range of lumbar flexion in both groups were significantly higher than before treatment (P<0.05), and the range of lumbar flexion in the Gutongling tincture group were significantly higher than that in the control group after eight weeks of treatment (P<0.05). The serum 5-HT and β-EP levels after eight weeks of treatment in two groups were lower than that before treatment (P<0.05), and the serum 5-HT and β-EP levels in the Gutongling tincture group were also decreased significantly compared with the control group (P<0.05). Conclusion The application of Gutongling tincture in patients with lumbar disc herniation can inhibit serum expression of 5-HT and β-EP, it can promote pain relief, improve the overall therapeutic effect of patients, and also improve the range of lumbar flexion of patients.

Key words: Gutongling tincture, lumbar disc herniation, 5-hydroxytryptamine, β- endorphins, lumbar flexion range