Influence of Complicated with OSAHS and OSAHS Severity on Left Heart Function and Risk of Cardiovascular Events in COPD Patients with Stable Stage

Abstract

Abstract: Objective To investigate the influence of complicated with OSAHS and OSAHS severity on left heart function and risk of cardiovascular events in COPD patients with stable stage. Methods 272 COPD patients with stable stage were retrospectively chosen in the period from January 2018 to January 2022 in our hospital. All patients were divided into the combined group (200 cases) and non-combined group (72 cases) according to combined with OSAHS or not, and mild group (123 cases), moderate group (45 cases) and severe group (32 cases) according to OSAHS severity. The general data, cardiopulmonary function indexes and prognostic indexes were analyzed. Multiple linear regression model was used to evaluate the independent relationship between AHI and related clinical indicators. Results The mean and minimum blood oxygen saturation at night in combined group were significantly lower than non-combined group（P<0.05）. The oxygen desaturation index, time proportion of blood oxygen saturation ≤90% and LVMI in combined group were significantly higher than those in non-combined group（P<0.05）. There were statistically significant differences in the incidence of E/e ', LAD, incidence of coronary heart disease and congestive heart failure among OSAHS severity subgroups（P<0.05）. Multiple linear regression analysis showed that E/ E 'was the dependent variable and AHI was the independent variable in the three models without adjusting for any factor, adjusted for age and BMI adjusted for age, sex, BMI, congestive heart failure history, history of coronary heart disease, history of hypertension, history of pulmonary heart disease and smoking status. E/e 'of patients with OSAHS higher with the increased of AHI level（P<0.05）. Conclusion The left heart function damage was more obvious and the risk of cardiovascular events was higher in stable stage COPD patients complicated with OSAHS and the severity of OSAHS was correlated with left heart function injury.

Key words: obstructive sleep apnea hypopnea syndrome, chronic obstructive pulmonary disease, stability, cardiac function

CLC Number:

HAN Jia-li. Influence of Complicated with OSAHS and OSAHS Severity on Left Heart Function and Risk of Cardiovascular Events in COPD Patients with Stable Stage[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(23): 61-64.

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