Effects of Gualoupi Injection and Rosuvastatin Calcium Tablets on Total Ischemia Load and QT Dispersion in Patients with Coronary Heart Disease and Angina Pectoris

Abstract

Abstract: Objective To investigate the effects of Gualoupi Injection combined with rosuvastatin calcium tablets on total myocardial ischemic load and QT dispersion in patients with coronary heart disease and angina pectoris. Methods A total of 140 patients with coronary heart disease and angina pectoris admitted to our hospital from January 2021 to December 2022 were selected as research subjects. All patients were divided into observation group and control group using random number table method, with 70 patients in each group. Patients in the control group were treated with rosuvastatin calcium tablets on the basis of conventional treatment, while patients in the observation group were treated with Gualoupi Injection and rosuvastatin calcium tablets on the basis of conventional treatment. The degree of angina pain, daily attack frequency, duration of each session, and daily nitroglycerin consumption of patients in the two groups were compared after treatment. The total myocardial ischemic load, QT dispersion, and changes in cardiac function were compared between the two groups before and after treatment. Results The pain score, daily attack frequency, duration of each episode, and daily nitroglycerin dosage in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the total myocardial ischemic load, QTd, and QTcd in both groups decreased, and the observation group was lower than the control group (P<0.05). After treatment, the 6-minute walking distance and LVEF of patients in both groups increased, and the BNP level in the observation group was significantly higher than that in the control group, while the BNP level in the observation group was lower than that in the control group (P<0.05). Conclusion Gualoupi Injection combined with rosuvastatin calcium tablets has a significant therapeutic effect on patients with coronary heart disease and angina pectoris, which can improve the number and frequency of angina pectoris attacks, alleviate pain, improve the total myocardial ischemia load and QT dispersion in patients, and enhance cardiac function. It is worthy of clinical application and promotion.

Key words: Gualoupi injection, rosuvastatin calcium tablets, coronary heart disease, angina pectoris, total load of myocardial ischemia, QTd

CLC Number:

R541.4

XIA Yang. Effects of Gualoupi Injection and Rosuvastatin Calcium Tablets on Total Ischemia Load and QT Dispersion in Patients with Coronary Heart Disease and Angina Pectoris[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(22): 34-37.

References

[1] AKBAR M R, PRANATA R, WIBOWO A, et al.The association between triglyceride-glucose index and major adverse cardiovascular events in patients with acute coronary syndrome - dose-response meta-analysis[J]. Nutr Metab Cardiovasc Dis,2021,31(11):3024-3030.
[2] LI M, LI H, LIU H, et al.Efficacy and safety of eight types Salvia miltiorrhiza injections in the treatment of unstable angina pectoris: A network meta-analysis[J]. Front Pharmacol,2022,13:972738.
[3] SHAO H, HUANG Y, XU D, et al.A Systematic Review and Meta-Analysis on the Efficacy of Puerarin Injection as Adjunctive Therapy for Unstable Angina Pectoris[J]. Front Cardiovasc Med,2022,9:763567.
[4] LI P, XIN Q, HUI J, et al.Efficacy and Safety of Tongxinluo Capsule as Adjunctive Treatment for Unstable Angina Pectoris: A Systematic Review and Meta-Analysis of Randomized Controlled Trials[J]. Front Pharmacol,2021,12:742978.
[5] 王霄,薛莉,常晶晶,等.稳心降脂活血汤联合瑞舒伐他汀钙对冠心病并发高血脂患者内皮功能的影响[J].陕西中医,2022,43(7):872-875.
[6] 苏布道,陈华,贺文帅.瑞舒伐他汀钙联合美托洛尔治疗冠心病合并心力衰竭的机制[J].西北药学杂志,2023,38(1):145-149.
[7] 刘爱娜,李继彬,徐佳新,等.基于网络药理学的瓜蒌皮注射液治疗冠心病稳定型心绞痛作用机制研究[J].现代药物与临床,2021,36(11):2238-2245.
[8] 吴兴利,杨丁友.全新冠心病防治指南[M].北京:军事医学科学出版社,2004:5-7.
[9] 吕晨,邹建玲,沈淑华,等.视觉模拟量表和语言评价量表用于术后疼痛评估的比较[J].全科医学临床与教育,2004,2(4):214-219.
[10] 景贤,赵映璇.瓜蒌皮注射液联合磷酸肌酸治疗冠心病稳定型心绞痛的临床研究[J].现代药物与临床,2022,37(9):2021-2025.
[11] 顾媛媛,仲昭辉,王琬玥,等.基于网络药理学的瓜蒌皮注射液治疗冠心病心绞痛作用机制探讨[J].临床药物治疗杂志,2022,20(2):47-54.
[12] 冯祝婷,钟金萍,朱艳,等.瓜蒌皮注射液的研究概况[J].海峡药学, 2021,33(10):10-13.
[13] 王新亮. 酒石酸美托洛尔缓释片联合阿司匹林对冠心病心绞痛患者QT离散度,血清细胞因子水平的影响[J].检验医学与临床,2022,19(15):2131-2134.
[14] 李为,朱坤,郑玉水,等.冠心病合并高血压患者血清C1q肿瘤坏死因子相关蛋白3及心肌缺血总负荷与心肌缺血的相关性[J].中国动脉硬化杂志,2021,29(6):529-533.
[15] 黄朝发,张榕华.瓜蒌皮注射液联合阿托伐他汀治疗冠心病的疗效和安全性评价[J].上海医药,2021,42(4):18-20.
[16] 谢玉霞,晋卫军,程璐,等.瓜蒌皮注射液联合西药治疗冠心病心绞痛(痰瘀互阻证)合并心衰患者的临床研究[J].实用中西医结合临床,2014,7(3):16-17,20.
[17] 杨玉婕,薛慧文,胡超群,等.瓜蒌皮水提物通过PI3K/Akt/eNOS信号通路抑制缺血缺氧大鼠原代心肌细胞的凋亡[J].厦门大学学报:自然科学版,2023,62(1):111-118.