Abstract: Objective To investigate and analyis the distribution and drug resistance of Coagulase-Negative Staphylococcus (CoNS) in elderly patients with blood-borne infection in Xi 'an HuYi District. Methods 686 cases of Xi 'an HuYi District patients in a certain area who were diagnosed and treated in the intensive care unit of Xi'an HuYi District Hospital of Traditional Chinese Medicine from October 2019 to December 2022 were selected as the study subjects, and the condition of blood-borne infection were determined, coagulase-negative staphylococci were isolated and drug resistance analysis were performed, and the general data of all patients were investigated and the influencing factors were analyzed. Results In the 686 patients, there were 82 cases (11.95%) of nosocomial blood-borne infection occurred. A total of 100 strains of pathogens were isolated, included 65 strains of gram-positive bacteria (included 20 strains of coagulase-negative staphylococcus) and 35 strains of gram-negative bacteria. In the strains of coagulase-negative Staphylococcus, the drug resistance rates to linezolid,penicillin, levofloxacin and ciprofloxacin were all exceeded 90.00%, the drug resistance rates to vancomycin and tegacyclin were all 0.00%, and the drug resistance rates to gentamicin and rifampicin were 60.00% and 15.00% respectively. The binary logistic regression analysis showed diabetes (β=1.482, OR=3.581, P<0.001), hypoproteinemia (β=3.113, OR = 3.117, P<0.001), intensive care unit stay (β=2.478, OR=2.841, P<0.001), drain placement (β=2.988, OR=1.893, P<0.001) as important factors of nosocomial bloodstream infection (P<0.05). Conclusion The incidence of blood borne infection in elderly ICU patients in Xi 'an HuYi District is relatively high, the proportion of coagulase negative staphylococci is relatively high, and they have extensive drug resistance. diabetes, hypoproteinemia, length of stay in intensive care unit, placement of drainage tubes, etc. are important factors leading to the occurrence of blood borne infection.

Key words: old age, intensive care unit, bloodborne infection, coagulase negative staphylococcus, drug resistance