Abstract: Objective To explore the effect of comprehensive use of albumin and phototherapy on the treatment of severe neonatal hyperbilirubinemia, and quantitatively analyze the impact of intervention on total bile acid (TBA) and total bilirubin (TSB) levels in children. Methods A total of 85 children with severe neonatal hyperbilirubinemia who received clinical intervention in Huaiyin District Maternal and Child Health Hospital of Huai'an City from January 2020 to December 2022 were selected as the study subjects. According to the difference in the intervention methods, the group was divided into study group (45 cases) and control group (40 cases). The study group was treated with albumin and phototherapy, and the control group received phototherapy alone. The clinical effects of the intervention and the changes in laboratory indicators such as TBA and TSB during the intervention were compared between the two groups, the incidence of different complications in the treatment of the two groups of children was statistically analyzed. Results The total response rate of patients was higher than the control group, the difference was statistically significant (P<0.05). The levels of TBA and TSB in the study group were lower than those in the control group during the 12-72 h intervention period (P<0.05). There was no difference in the levels of HS-CRP and FFA between the two groups before intervention (P>0.05). After intervention, the levels of HS-CRP and FFA in the study group were lower than those in the control group (P<0.05). The incidence of adverse reactions in the study group and the control group were insignificant (P>0.05). Conclusion Albumin combined with phototherapy has a good intervention effect on children with severe neonatal hyperbilirubinemia, can significantly reduce the levels of TBA and TSB in newborns, and is safe for treatment, which is worthy of clinical promotion and application.

Key words: albumin, phototherapy, severe neonatal hyperbilirubinemia, TBA, TSB, horizontal impact