Study on the Relationship between D-dimer and Deep Vein Thrombosis in Patients with Fractures of Different Sites of Lower Extremities

Abstract

Abstract: Objective The aim of this study is to explore the relationship between D-dimer and deep vein thrombosis in patients with fractures of different sites of the lower extremities through level detection of D-dimer before and after operation. Methods A total of 164 patients with lower extremity fractures whom received treatment in our hospital were recruited from January 2019 to February 2022. According to with or without deep vein thrombosis of lower extremities, the patients were divided into observation group (n=35) and control group (n=129) . Based on the results of D-dimer detection and color Doppler ultrasound, the incidence of deep vein thrombosis in two groups were compared and the D-dimer level of patients with fractures in different sites were analyzed between and in two groups. Results The levels of D-dimer in patients with hip and knee fractures were significantly higher than that in patients with ankle fractures (P< 0.05), and the incidences of deep vein thrombosis in patients with hip and knee fractures were significantly higher than that in patients with ankle fractures (P<0.05). The D-dimer level of patients in the control group decreased gradually after operation, and the D-dimer level of patients in the observation group was significantly higher than that in the control group on the 1st day, 3rd day, 7th day, and 15th day after operation (P<0.05). Conclusion The fracture site is an independent risk factor for the occurrence of deep vein thrombosis. The detection of plasma D-dimer in fracture patients is helpful to detect the existing risk of deep vein thrombosis in time, thereby taking early intervention measures and reducing the incidence of clinical deep vein thrombosis.

Key words: D-dimer, deep vein thrombosis, risk factor

CLC Number:

R683.4

ZHU Wei, XU Xiao-feng, CHEN Ye-xin, ZHOU Feng, TAN Xin, XIA Na, MAO Jian-hai. Study on the Relationship between D-dimer and Deep Vein Thrombosis in Patients with Fractures of Different Sites of Lower Extremities[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(21): 8-11.

References

[1] 冯玉倩,张少韶,余淼.下肢深静脉血栓合并肺栓塞的危险因素分析[J].华中科技大学学报(医学版),2016,45(3):319-323.
[2] 田锦林,王海峰,屈尔青.下肢深静脉血栓患者非高危肺栓塞危险的多因素分析[J].中国临床医学影像杂志,2015,26(10):692-695.
[3] 鲁会田. D-二聚体水平检测对下肢骨折术后深静脉血栓早期诊断的作用[J].中国实用医刊,2015,42(24):104-105.
[4] 付亚辉,王鹏飞,王宝辉,等.老年髋部骨折患者围手术期深静脉血栓形成的发生规律及血浆D-二聚体的变化特点[J].中华创伤骨科杂志,2016,18(8):668-672.
[5] 王宝辉,王鹏飞,付亚辉,等.踝关节周围骨折患者深静脉血栓形成的发病及静脉血栓形成危险度评分和D-二聚体的诊断价值[J].中华创伤骨折杂志,2015,27(12):1029.
[6] 尚青龙,李伟,谭一,等.D-二聚体检测在骨折患者下肢深静脉血栓中的诊断价值[J].中国骨与关节杂志,2018,7(11):854-857.
[7] 李海华,姚雪玉,伍瑞忠.探讨D-二聚体检测在骨折患者下肢深静脉血栓中的诊断价值[J].吉林医学,2019,40(1):36-38.
[8] 项凡. 彩色多普勒超声诊断下肢深静脉血栓的有效性分析[J].中国实用医药,2020,15(7):93-95.
[9] 徐金平,李芸.Wells评分及D-二聚体测定在高龄髋部骨折患者围术期下肢深静脉血栓预测中的应用价值[J].中国当代医药,2019,26(4):118-120.
[10] 孙少君,王晓明.Wells评分联合D-二聚体预测下肢深静脉血栓的价值[J].实用医学杂志,2016,32(1):98-101.
[11] 赵纪春,邱贵兴,裴福兴,等.骨科大手术加速康复围手术期静脉血栓栓塞症防治专家共识[J].中华骨与关节外科杂志,2022,15(10):754-762.
[12] 臧加成,马信龙,马剑雄,等.不同部位骨折深静脉血栓发生率的流行病学研究[J].中华骨科杂志,2016,36(9):540-545.
[13] 费晨,魏巍,张斌飞,等.胫骨平台骨折患者围手术期下肢深静脉血栓形成发生规律及危险因素分析[J].中华创伤骨科杂志,2019,21(2):102-108.
[14] LIU C, SONG Y, ZHAO J, et al.Elevated D-dimer and fibrinogen levels in serum of preoperative bone fracture patients[J]. Springer Plus, 2016, 5(161):1-5.
[15] YIN X, LIU P, LIU B Y, et al.Preventive effects of low molecular weight heparin on formation of deep vein thrombosis by reducing D dimer values in patients undergoing spinal surgery[J]. EurRev Med Pharmacol Sci, 2018,22(1):229-237.
[16] SHIQING W, SHENGZHONG M, CHENG Z, et al.Efficacy of low molecular weight heparin in spinal trauma patients after part concentrated screw surgery and its influence on blood parameters and the incidence of deep venous thrombosis[J]. Med Hypotheses,2019,132:109330.