Abstract: Objective To investigate the association between rs2272394, rs2272395 and rs2272400 polymorphisms of SLC6A11 gene and drug-resistant epilepsy. Methods Formulate a literature search plan, and search the Chinese and foreign literature related toSLC6A11 gene polymorphisms. PubMed, Embase, Cochrane Library, Web of Science, China []National Knowledge Infrastructure, Wan-fang Data Knowledge Service Platform, and China Science and Technology Journal Database were searched for relevant studies. The two people jointly screened the literature, extracted the data and cross-checked, and after evaluating the quality of the included literature, the literature that met the criteria was included. Meta-analysis of the literature using R4.2.1 software was performed and a genetic model was used for analysis. ResultNine studies from four studies were included, with a total of 1 172 cases in the drug-resistant group and 1 340 cases in the drug-responsive group. For alleles C and T, OR=0.89, 95%CI= 0.79~1.01 were obtained by fixed effect model. After excluding one marginal study, the results showed that OR=0.93, 95%CI= 0.82~1.06; the OR=0.79, 95%CI=0.67~0.92 of the recessive gene model CC/TC+TT; the OR of dominant gene model TT/TC+CC was 0.99, and 95%CI=0.80~1.23; the OR=0.86, 95%CI=0.63~1.16 of the additive gene model CC/TT; the OR=0.83 of the over-dominant gene model TT+CC/TC, and 95%CI=0.72~0.97. Conclusion There is currently no clear evidence that rs2272394, rs2272395 and rs2272400 polymorphisms of SLC6A11 gene are associated with drug-resistant epilepsy.

Key words: drug-resistant epilepsy, SLC6A11, epilepsy, genetic polymorphism.