Abstract: Objective To explore the application effect of sequential organ failure (SOFA) score in assessing the incidence of multiple organ failure in intensive care unit. Methods A total of 50 patients with multiple organ failure admitted to the intensive care unit of our hospital from January 2021 to January 2023 were selected as the study subjects, and divided into the observation group, and 50 patients who were treated in the intensive care unit at the same time were selected as the control group. The SOFA scores of the two groups were compared, and the diagnostic efficacy of SOFA scores on multiple organ failure was analyzed. All patients were followed up in the hospital, 21 patients who died 28 days in the hospital were divided into death group, and the remaining 29 patients were divided into survival group. The general clinical conditions of the two groups were compared, and the prognostic value of SOFA score for multiple organ failure in intensive care unit was analyzed. Results The SOFA score of patients in the control group was lower than that in the observation group (P<0.05). By drawing the ROC curve, the results showed that the area under the curve of SOFA score diagnosis of multiple organ failure was 0.832, the specificity was 91.47%, the sensitivity was 73.59%, and the area under the curve of clinical comprehensive diagnosis was 0.891, the specificity was 98.52%, the sensitivity was 90.26%. There was no significant difference between the survival group and the death group in terms of sex, BMI, basic disease, and time of admission to ICU (P>0.05), but there was significant difference between the survival group and the death group in terms of age, APACHE II score, and SOFA score (P<0.05). The results of logistic regression analysis showed that SOFA score was an independent predictor of multiple organ failure (P<0.05). Conclusion SOFA score can effectively evaluate the occurrence of multiple organ failure in intensive care unit with high sensitivity and specificity. Meanwhile, SOFA score can also help predict the prognosis of multiple organ failure in intensive care unit. Clinically, patients with high SOFA scores need to improve the treatment plan in time to prevent the occurrence of poor prognosis.

Key words: sequential organ failure score, ICU, multiple organ failure, prognosis prediction, diagnostic value