Abstract: Objective To analyze the efficacy of endoscopic submucosal dissection in the treatment of early gastric cancer and the risk factors related to postoperative recurrence, so as to provide evidence for ESD treatment of early gastric cancer. Methods 200 cases of early gastric cancer treated with ESD in Liaocheng People's Hospital from January 2017 to January 2019 were selected, and the gender, age, family history, presence of Helicobacter pylori infection, tumor size, differentiation, pathological type, metastasis, treatment and clinical manifestation of all patients were recorded. To analyze the efficacy of ESD in the treatment of early gastric cancer. After 3 years of follow-up, the patients were divided into two groups according to the follow-up. Results postoperative recurrence group and postoperative non-recurrence group. The basic situation and clinical data of patients in the two groups were compared, and the risk factors related to postoperative recurrence were analyzed by logistic regression. Results Survival of patients: The follow-up time of this study was 10~36 months. As of January 30,2022,the average follow-up time was (30.35 ± 5.01) months. There were no deaths. Recurrence of patients: 26 of 200 patients with early gastric cancer treated with ESD recurred, with a recurrence rate of 13.0%. All relapsed patients were treated with ESD again and achieved long-term survival. Through univariate and multivariate analysis of postoperative recurrence of early gastric cancer patients treated with ESD, it was found that tumor size (OR: 3.981, 95% CI: 1.077 ~ 2.991), depth of invasion (OR: 2.945, 95% CI: 1.946 ~ 4.997), histological classification (OR: 2.909, 95% CI: 1.964 ~ 6.964) were independent risk factors for postoperative recurrence. Conclusion ESD has a good clinical effect in the treatment of early gastric cancer.Tumor size, depth of invasion and histological classification are independent risk factors for postoperative recurrence.

Key words: endoscopic submucosal dissection, early gastric cancer, efficacy, postoperative recurrence, risk factors