Abstract: Objective To observe the therapeutic effect and related indexes of continuous renal replacement therapy (CRRT) in the treatment of enteral nutrition in patients with sepsis. Methods Sixty patients with sepsis (from February 2020 to February 2022) in Yunnan Central Hospital of Honghe Prefecture (Gejiu City People's Hospital) were selected and randomly divided into control group (30 cases) with CRRT and observation group (30 cases) with CRRT and enteral nutrition intervention. PA, HB, ALB, CRP, IL-6, IL-8, TNF-α, APACHE Ⅱscore, SOFA, gastric residual, abdominal pressure of the two groups were detected and compared. Results After intervention, the levels of PA, HB and ALB in 2 groups were increased, and the above indexes in observation group were higher than control group after intervention(P<0.05). After intervention, the levels of CRP, IL-6, IL-8 and TNF-α were decreased in both groups, and the above indexes in observation group were decreased more than control group after intervention(P<0.05). The incidence of complications was 3.33% in observation group and 20.00% in control group, which was lower in observation group than in control group(P<0.05). After intervention, APACHE Ⅱ and SOFA scores of both groups were decreased, and the above indexes of observation group were reduced more than control group after intervention(P<0.05). After intervention, gastric residual and abdominal pressure were decreased in both groups, and the above indexes in the observation group were reduced more than that in the control group after intervention (P<0.05). Conclusion CRRT and enteral nutrition intervention in sepsis patients can improve the nutritional status of patients, reduce inflammatory response, effectively improve the condition, reduce gastric residual and abdominal pressure, which is worth learning.

Key words: sepsis, CRRT, enteral nutrition intervention