Abstract: Objective To observe the sedative effect of dexmedetomidine hydrochloride on patients under spinal anesthesia. Methods A total of 60 patients [The American Society of Anesthesiologists (ASA) is graded II] were selected from Jinzhou Central Hospital. Using random number table method, the patients were divided into 3 groups (n=20): control group (group A), dexmedetomidine atomization inhalation group (group B) and dexmedetomidine oral spray group (C group). The sedation scores and heart rate changes of patients entering the room (T0) and after anesthesia (T1) after dexmedetomidine administration were recorded at 10 minutes (T2), 20 minutes (T3) and 30 minutes (T4), and the time to sleep after administration in patients with scleropractic combined anesthesia is recorded. The incidence of adverse reactions such as bradycardia and hypotension in each group were recorded. Results Compared with group A, there was no significant difference in the changes of heart rate and sedation score in group B at each time point (P>0.05). with T0 and T1 in group C, the heart rate decreased and the sedation score increased, with a statistically significant difference (P<0.05), but there was no significant difference compared with T4 (P>0.05). Among them, patients in group C could enter sleep state after administration, and the time to fall asleep was (60.15±7.66) min after administration. Among the three groups of patients, only 2 cases of short-term choking occurred in group C, and no adverse reactions were observed in other patients. Conclusion Compared with the control group, there was no significant change in the administration mode of dexmedetomidine hydrochloride 1.5 μg/kg through oral atomization. The administration mode of dexmedetomidine hydrochloride through buccal mucosa spray could produce better sedative effect.

Key words: dexmedetomidine hydrochloride, sedation score, oral administration