Abstract: Objective To investigate and analysis the effects of Shexiang Baoxin Pill combined with trimetazidine hydrochloride tablets in the treatment of elderly patients with unstable angina pectoris and its influence on heart function and blood lipid level. Methods From March 2020 to March 2021, 180 cases of elderly patients with unstable angina pectoris diagnosed and treated in our hospital were selected as the study objects. Accorded to the random number table method, the patients were divided into the combined group and the traditional group with 90 cases in each groups. The traditional group was treated with trimetazidine hydrochloride, and the combined group was treated with Shexiang Baoxin Pill on the basis of the traditional group. All the cases were to determine the treatment effects and cardiovascular adverse events, and to detect the changes of cardiac function and blood lipid levels. Results After treatment, the total effective rates of the combined group were significantly higher than that of the traditional group ( P<0.05). The levels of TC, TG and LDL-C in the combined group and the traditional group after treatment were significantly lower than those before treatment (P<0.05), and HDL-C were also significantly higher than those before treatment (P<0.05). There were also significant difference compared between the combined group and the traditional group after treatment (P<0.05). The ventricular end diastolic diameter and ventricular end systolic diameter in the combined group and the traditional group after treatment were significantly lower than those before treatment, left ventricular ejection fraction were all higher than before treatment (P<0.05), and there were also significant difference compared between the combined group and the traditional group after treatment (P<0.05). At 1-year of follow-up after treatment, the incidence rates of major cardiovascular adverse events such as recurrent angina pectoris, myocardial infarction, cardiac death and heart failure was lower than in the traditional group, and the statistical analysis did not differ (P>0.05). Conclusion The combination of Shexiang Baoxin Pill and Trimetazidine Hydrochloride Tablets in the treatment of elderly patients with unstable angina pectoris can improve the cardiac function, improve the therapeutic effect, improve the blood lipid level of patients, and will not increase the incidence of cardiovascular adverse events.

Key words: shexiang baoxin pill, trimetazidine hydrochloride, aged, unstable angina pectoris, cardiac function, blood lipid level