Efficacy Evaluation of Saccharomyces Boulardii Powder Combined with Mesalazine in the Treatment of Moderate and Mild Ulcerative Colitis

Abstract

Abstract: Objective To investigate the therapeutic effect of Saccharomyces boulardii powder + Mesalazine on moderate to mild ulcerative colitis (UC). Methods A total of 88 patients with moderate and mild ulcerative colitis admitted to Hospital of Dunhua City from January 2021 to December 2021 were selected. They were divided into groups according to the random number table method. 44 cases in the control group were treated with Mesalazine, and 44 cases in the observation group were treated with Saccharomyces boulardii powder + Mesalazine, the curative effect of two groups were compared. Results Compared with the total effective rate, the observation group was higher than the control group (P<0.05). After treatment, the serum tumor necrosis factor-α (TNF-α), interleukin-6 (interleukin-6, IL-6) and interleukin-10 (interleukin-10, IL-10) levels were lower than those in the control group (P<0.05); The endoscopic score and related symptom scores in the observation group after treatment were lower than those in the control group (P<0.05). There was no significant difference in adverse reaction rate between two groups (P>0.05). Conclusion Compared with Mesalazine alone in patients with moderate to mild UC, the combined treatment of Saccharomyces boulardii powder + Mesalazine is more effective, significantly reduces serum inflammatory factors, relieves symptoms, and reduces endoscopic scores, and fewer adverse reactions and better safety.

Key words: ulcerative colitis, Saccharomyces boulardii powder, mesalazine

CLC Number:

R574.62

HUO Yan. Efficacy Evaluation of Saccharomyces Boulardii Powder Combined with Mesalazine in the Treatment of Moderate and Mild Ulcerative Colitis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(1): 50-53.

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