Application of Serum Total IgE and Allergen-Specific IgE Combined with Eosinophil Detection in the Diagnosis of Atopic Dermatitis

Abstract

Abstract: Objective To investigate the clinical value of serum total immunoglobulin E (IgE), allergen-specific IgE (sIgE) combined with eosinophils (EOS) in the diagnosis of atopic dermatitis. Methods The clinical data of 72 patients with atopic dermatitis admitted to Rizhao City Dermatology Prevention and Treatment Center from January 2020 to January 2022 were retrospectively analyzed and included in the observation group. All selected subjects were collected blood to detect serum total IgE, sIgE and EOS levels. Serum levels of total IgE, sIgE, and EOS were compared between the two groups, and the severity of atopic dermatitis patients was graded by SCORAD score, and the levels of total IgE, sIgE, and EOS between different severity levels were compared; Positive detection in patients with atopic dermatitis; receiver operating curve (ROC) was drawn to analyze the clinical value of serum total IgE, sIgE, EOS and combined detection in the diagnosis of atopic dermatitis; Pearson correlation analysis was used Correlation between serum total IgE, sIgE and EOS levels and severity. Results The serum total IgE,sIgE and EOS levels in the observation group were higher than those in the control group,and the difference was statistically significant (P<0.05);the positive rate of combined detection was higher than that of total IgE,sIgE and EOS single detection, and the difference was statistically significant (P<0.05).The areas under the curve (AUC) for the detection and diagnosis of atopic dermatitis were:0.808,0.828,0.746,and 0.963,respectively,and the combined detection had the highest diagnostic value;serum total IgE,sIgE and EOS levels were positively correlated with the SCORAD score (r=0.421,0.513,0.387,P<0.05). Conclusion Serum total IgE,sIgE combined with EOS detection can improve the diagnostic accuracy of atopic dermatitis,and the above indicators are positively correlated with the severity of the disease,which can provide a reference for clarifying the patient’s condition.

Key words: atopic dermatitis, immunoglobulin E, eosinophils, diagnostic value

CLC Number:

R446.62

WANG Yun-peng, YANG Rui-hai, LI Fang, LI Gui-shuang. Application of Serum Total IgE and Allergen-Specific IgE Combined with Eosinophil Detection in the Diagnosis of Atopic Dermatitis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(1): 19-22.

References

[1] 姜昌明,黄晓莺.健脾祛风汤治疗特应性皮炎的疗效及对患者血清总IgE和外周血嗜酸细胞的影响[J].四川中医,2019,37(6):136-138.
[2] Jin S O, Seong G S, Yong D K, et al.Effects of Deacetylasperulosidic Acid on Atopic Dermatitis through Modulating Immune Balance and Skin Barrier Function in HaCaT,HMC-1,and EOL-1 Cells.[J]. Molecules,2021,26(11):3298.
[3] 李志,杨婷婷,李文哲.特应性皮炎患者外周血中Th22、Treg细胞及其细胞因子表达的研究[J].中国实验诊断学,2019,23(5):788-791.
[4] 李泉,席艳.血清IgG及特异性IgE联合检测在儿童过敏性疾病过敏原筛查中的应用[J].贵州医药,2020,44(6):969-970.
[5] 曾瑜,卫风蕾.血清特异性IgE与斑贴试验在特应性皮炎过敏原检测中的应用研究[J].检验医学与临床,2022,19(4):554-556.
[6] 潘威,朱影,毛国顺,等.血清总IgE和过敏原特异性IgE检测在5岁以下儿童哮喘临床诊断中的价值[J].中国医药导报,2022,19(14):81-83,87.
[7] 中华医学会皮肤性病学分会免疫学组,特应性皮炎协作研究中心.中国特应性皮炎诊疗指南(2014版)[J].中华皮肤科杂志,2014,47(7):511-514.
[8] 徐爽,丁杨峰,易雪梅,等.中药黄连膏湿包联合糖皮质激素软膏外用治疗成人中,重度特应性皮炎的疗效观察[J].中国中西医结合皮肤性病学杂志,2020,19(6):575-576.
[9] Lin V, Patel R, Wirtz A, et al.Evaluation of Spin in the Abstracts of Systematic Reviews and Meta-Analyses of Atopic Dermatitis Treatments and Interventions[J].Dermatology,2021,237(4):1-10.
[10] 卢静静,郑源泉,王攀,等.序贯外用糠酸莫米松乳膏与他克莫司软膏治疗儿童特应性皮炎的临床观察[J].临床皮肤科杂志,2019,48(11):695-697.
[11] 陈纯,闵玮,于亚峰,等.苏州地区变应性鼻炎和特应性皮炎患者过敏原特异性IgE的对比分析[J].中国中西医结合耳鼻咽喉科杂志,2021,29(3):195-199.
[12] 张幸,陈信,吕曹华.儿童特应性皮炎的严重程度与血清25-羟维生素D和总IgE的相关性[J].中国妇幼保健,2022,37(1):81-83.
[13] 乔彦明,白芸芸.过敏性咳嗽合并过敏性鼻炎患儿血清总IgE、外周血嗜酸性粒细胞、阳性过敏原种类与呼出气一氧化氮间的关系[J].检验医学与临床,2022,19(9):1166-1169.
[14] 黄焕杰,杨贤平,陈逴凡,等.14~55岁特应性皮炎患者严重程度与维生素D、总IgE和嗜酸性粒细胞的相关性[J].中国皮肤性病学杂志,2021,35(3):272-276.
[15] 孟凡超,赵宗玲,刘晶晶,等.1878例过敏性疾病成年患者血清过敏原特异性IgE检测及流行病学特征分析[J].华南预防医学,2021,47(12):1536-1539,1544.
[16] 魏薇,何金昌,余素君.抗环瓜氨酸肽抗体、抗突变型瓜氨酸波形蛋白抗体和嗜酸性粒细胞联合检测在早期类风湿关节炎中的诊断价值[J].实用医院临床杂志,2020,17(4):188-191.
[17] 金国松. 炎性因子、嗜酸性粒细胞在变应性鼻炎患儿中的水平变化及作用机制[J].中国眼耳鼻喉科杂志,2019,19(3):183-185.