Abstract: Objective To investigate the effect of Chaihujia Longgu Muli Decoction combined with flupentixol and melitracen in the treatment of post-stroke depression. Methods Selected 120 cases of patients with post-stroke depression who were treated in Qingyang Hospital of Traditional Chinese Medicine, Gansu Province of April 2020 to January 2022, divided into two groups randomly. The control group was treated with flupentixol and melitracen alone, and the observation group was treated with Chaihujia Longgu Muli Decoction. The HAMD scale factors of the patients with post-stroke depression in the two groups were evaluated, and the serum norepinephrine and serotonin levels were detected in the two groups. Results The effective rate of the observation group was significantly higher than control group (P<0.05). Before treatment, there was no significant difference in the scores of body weight, anxiety, sleep disturbance, day and night, block, hopelessness and cognitive impairment between the two groups (P>0.05). After treatment, the scores of body weight, anxiety, sleep disturbance, day and night, block, sense of hopelessness and cognitive impairment in both groups were significantly decreased (P<0.05), and the scores of body mass, anxiety, sleep disturbance, day and night, block, sense of hopelessness and cognitive impairment in the observation group were significantly lower than those in the control group (P<0.05). Before treatment, there was no significant difference in the levels of serum norepinephrine and serotonin between the two groups (P>0.05). After treatment, the levels of serum norepinephrine and serotonin in the two groups were significantly increased (P<0.05), and the serum levels of norepinephrine and serotonin in the observation group were significantly higher than those in the control group (P<0.05). Conclusion Chaihujia Longgu Muli Decoction combined with flupentixol and melitracen has a significant effect on post-stroke depression, which is worthy of promotion.

Key words: Chaihujia Longgu Muli Decoction, flupentixol and melitracen, clinical efficacy, post-stroke depression