Correlation Analysis of Serum TSH and TPO-Ab Expression Levels with Hypothyroidism in the Elderly

Abstract

Abstract: Objective To explore and analysis the correlation between the expression levels of serum Thyroid-stimulating hormone (TSH), Thyroid peroxidase antibody (TPO-Ab) and senile hypothyroidism. Methods A total of 90 elderly patients with hypothyroidism who were diagnosed and treated in Nanjing Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Nanjing University of Traditional Chinese Medicine from January 2018 to December 2021 were retrospectively selected as the research subjects, and 40 cases of primary hypothyroidism and 50 cases of subclinical hypothyroidism were included. The serum TSH and TPO-Ab expression levels of the patients were detected. At the same time, the blood lipid and hemoglobin levels of the patients were detected, and the correlation between the expression levels of serum TSH and TPO-Ab and the elderly hypothyroidism was analyzed. Results There were no difference in serum TSH content compared between the two groups, and the difference was statistically significant (P<0.05). The serum TPO-Ab content in the hypothyroidism group were higher than that in the hypothyroidism group, and the difference was statistically significant (P<0.05). There were no difference in hemoglobin and blood lipid indexes [(triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol(HDL-C)]compared between the two groups (P>0.05). The proportion of symptoms such as lethargy and fatigue in the hypothyroidism group were higher than that in the hypothyroidism group, the difference is statistically significant (P<0.05). In the 90 patients, Pearson analysis showed that serum TSH levels were not correlated with subclinical hypothyroidism (P>0.05), but serum TPO-Ab were correlated with subclinical hypothyroidism (P<0.05). Conclusion Subclinical hypothyroidism in the elderly is the main type of hypothyroidism. The expression level of serum TPO-Ab is lower than that in patients with primary hypothyroidism. There is correlation between the expression level of serum TPO-Ab and subclinical hypothyroidism in the elderly.Detection of serum TSH and TPO-Ab expression levels is helpful to predict the occurrence of subclinical hypothyroidism in the elderly.

Key words: elderly, hypothyroidism, thyroid peroxidase antibody, thyroid stimulating hormone, subclinical hypothyroidism, relevance

CLC Number:

R581.2

WU Bing-si. Correlation Analysis of Serum TSH and TPO-Ab Expression Levels with Hypothyroidism in the Elderly[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(24): 15-19.

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