Abstract: Objective To investigate the effect of laparoscopic ureteropelvic plasty (LDP) on hydronephrosis in children with ureteropelvic junction obstruction (UPJO) and its influence on renal function. Methods A retrospective selection of 85 children with UPJO hydronephrosis who were treated in the People's Hospital of Ningxia Hui Autonomous Region from January 2019 to January 2022 were selected and divided into observation group (n=43, LDP) and control group (n=42, open pyeloplasty) according to the surgical methods. Operation indexes(operation time, hospitalization expenses, intraoperative blood loss, total amount of perirenal drainage, postoperative analgesic dosage and hospitalization time), renal function, renal morphology and complications were compared between the two groups. Results Compared with the control group, the operation time and hospitalization expenses in the observation group increased significantly (P<0.05). Compared with the control group, blood loss during operation, the total amount of perirenal drainage, postoperative analgesic dosage and postoperative hospitalization time were significantly reduced (P<0.05). After operation, the glomerular filtration rate (GFR) of both groups was significantly higher than that before operation, and the Serum creatinine (Scr) level was significantly lower than that before operation (P<0.05). However, there was no significant difference in GFR and Scr levels between the two groups (P>0.05). The incidence of postoperative complications in the observation group was significantly lower than that in the control group (P<0.05). After operation, the renal volume of both groups decreased significantly (P<0.05) and the renal parenchyma thickness increased significantly (P<0.05). However, there was no significant difference in renal volume and renal parenchyma thickness between the two groups (P>0.05). Conclusion LDP is effective in the treatment of children with UPJO hydronephrosis, which can promote the recovery of renal function and renal morphology and reduce postoperative complications.

Key words: severed pyeloureteroplasty, laparoscopy, ureteropelvic junction obstruction, hydronephrosis, kidney function