Effect of Zhuangguzhitong Capsule on Postmenopausal Osteoporotic Vertebral Compression Fracture Patients after PVP

Abstract

Abstract: Objective To explore and analysis the effects of Zhuangguzhitong capsule on postmenopausal osteoporotic vertebral compression fractures after percutaneous vertebroplasty （PVP）. Methods A total of 96 postmenopausal patients with osteoporotic vertebral compression fractures who completed PVP surgery in Qingyang Traditional Chinese Medicine Hospital from May 2019 to January 2022 were selected as the research subjects, and the patients were equally divided into the traditional Chinese medicine group and the control group accorded to the simple random number table method. The control group were given routine physical therapy, and the traditional Chinese medicine group were given Zhuanggu Zhitong Capsule on the basis of the treatment of the control group. The two groups were treated for 3 months. The VAS thoracolumbar back pain score, ODI spine score, lumbar vertebral bone mineral density changes, and complications during treatment were compared between the two groups before and after treatment. Results The VAS thoracolumbar back pain scores in two groups after treatment were lower than those before treatment （P<0.05）, and the traditional Chinese medicine group were also significantly lower than that in the control group （P<0.05）. The ODI spine scores in two groups after treatment were significantly lower than those before treatment （P<0.05）, and the traditional Chinese medicine group were also significantly lower than that in the control group （P<0.05）. After treatment, the bone mineral density of lumbar vertebrae in two groups were significantly higher than that before treatment （P<0.05）, and the traditional Chinese medicine group were also significantly higher than that in the control group after treatment （P<0.05）. The incidence of complications such as vertebral body refracture, lower extremity deep venous thrombosis, bedsore, and pneumonia in the traditional Chinese medicine group were significantly lower than that in the control group （P<0.05）. Conclusion The application of Zhuanggu Zhitong Capsules in postmenopausal osteoporotic vertebral compression fracture patients after PVP can reduce the incidence of complications, improve the bone mineral density of the patients, and also promote the relief of thoracolumbar back pain and improve the lumbar spine function of the patients.

Key words: zhuangguzhitong capsule, menopause, osteoporotic vertebral compression fracture, percutaneous vertebroplasty, pain, bone mineral density

CLC Number:

R683.2

HAN Jun-bu. Effect of Zhuangguzhitong Capsule on Postmenopausal Osteoporotic Vertebral Compression Fracture Patients after PVP[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(22): 168-171.

References

[1] Láinez Ramos-Bossini A J, López Zúñiga D, Ruiz Santiago F.Percutaneous vertebroplasty versus conservative treatment and placebo in osteoporotic vertebral fractures: meta-analysis and critical review of the literature[J]. Eur Radiol,2021,31(11):8542-8553.
[2] 朱一鹏,杨志昌,吴照龙.比较分析PKP联合不同抗骨质疏松药物治疗骨质疏松性脊柱压缩骨折的临床疗效[J].中华养生保健,2022,40(14):72-74,135.
[3] 周霖,王肖辉,李砺锋,等.基于网络药理学探讨复方伤痛胶囊治疗骨折的作用机制研究[J].成都中医药大学学报,2022,45(1):37-43.
[4] 尹啸飞,周正新,韩朝永.益肾活血方联合股骨近端防旋髓内钉治疗骨质疏松性股骨转子间骨折的疗效和安全性[J].广州中医药大学学报,2022,39(3):533-539.
[5] 王皓,凃峰,赵文斌,等.基于BMP-2/SMAD/Runx2通路探究骨化三醇胶囊对大鼠胫骨骨折愈合的影响[J].中国骨质疏松杂志,2022, 28(1):47-51.
[6] 闫亮,吕守正,张健,等.壮骨止痛胶囊联合雷洛昔芬治疗绝经后骨质疏松症的临床研究[J].现代药物与临床,2021,36(8):1715-1718.
[7] 邢宝瑞,冯娜娜,张娟,等.红元胶囊联合多模式镇痛对老年股骨粗隆间骨折围手术期镇痛效果的影响[J].河北中医,2022,44(1):39-42.
[8] 杨珊珊,陈红琼,陈瑶,等.壮骨止痛胶囊对去卵巢大鼠体质量及脂/骨代谢的影响[J].湖南中医药大学学报,2022,42(1):18-24.
[9] 吴钒,吴华珍,黄志辉,等.补肾壮骨丸对初次椎体成形术后伤椎再塌陷的防治作用[J].实用医学杂志,2022,38(1):111-115.
[10] 李琰,孙鹏,孙晋客,等.消肿止痛胶囊在Danis-Weber C型踝关节骨折术前治疗中的应用[J].中医正骨,2022,34(5):17-20,27.
[11] 黄跃华,李勇,董冬,等.仙灵骨葆胶囊联合骨肽片治疗桡骨远端骨折的临床研究[J].现代药物与临床,2022,37(4):818-821.
[12] 魏伟强,贺健军,蒋腾龙,等.PKP联合四烯甲萘醌治疗绝经后女性骨质疏松性胸腰压缩骨折的疗效分析[J].湖南师范大学学报(医学版),2022,19(2):55-58.
[13] 王鸥,夏维波,成志峰,等.金天格胶囊治疗原发性骨质疏松症的有效性及安全性:随机、双盲双模拟、阳性药平行对照、多中心临床试验[J].中华骨质疏松和骨矿盐疾病杂志,2022,15(2):142-151.
[14] 刘炜,罗会盛,邹恺平,等.健骨丸对去势大鼠骨质疏松性骨折愈合的影响[J].中草药,2021,52(18):5615-5619.
[15] 黄振峰,王建,陈梦妮,等.仙灵骨葆胶囊对骨质疏松性骨折大鼠骨生长因子及骨折愈合的影响[J].中国骨质疏松杂志,2021,27(12): 1833-1837.
[16] 杜鑫冲,王军,王燕波,等.唑来膦酸用于骨质疏松性椎体压缩性骨折患者经皮椎体后凸成形术后疗效观察[J].中国药业,2021,30(11): 77-80.
[17] 江涛,侯秋科,陈善创,等.骨松安促进骨质疏松大鼠骨折愈合的信号通路研究[J].中国中医骨伤科杂志,2021,29(12):6-11.
[18] 叶丙霖,李淑玲,王想福,等.陇中损伤胶囊对老年性骨质疏松性椎体压缩骨折患者Wnt/β-catenin信号通路的影响[J].西部中医药,2021,34(6):99-102.
[19] Li Y, Feng X, Pan J, et al.Percutaneous Vertebroplasty Versus Kyphoplasty for Thoracolumbar Osteoporotic Vertebral Compression Fractures in Patients with Distant Lumbosacral Pain[J].Pain Physician,2021,24(3):E349-E356.
[20] 张妍妍,苏坤智,秦小燕.仙灵骨葆胶囊联合碳酸钙、骨化三醇对绝经后骨质疏松椎体压缩骨折PVP术后患者的临床疗效[J].中成药,2022,44(2):683-685.