Abstract: Objective To explore the predictive value of D-dimer, lactate dehydrogenase and CRP in children with refractory mycoplasma pneumoniae pneumonia. Methods Forty-two cases of Refractory Mycoplasma pneumoniae pneumonia admitted to the Suqian Hospital of Nanjing Drum Tower Hospital Group from January 2020 to May 2022 were selected. Children with RMPP (RMPP group) and 77 children with general Mycoplasma pneumoniae pneumonia (GMPP group) were included in this study. The difference of D-dimer, lactate dehydrogenase and CRP concentration levels between the two groups was compared, and the ROC curve of the evaluation value of the three indicators for RMPP was drawn to find the maximum cut off value of each predictor and determine its sensitivity and specificity. Results The levels of D-dimer, lactate dehydrogenase and CRP in RMPP group were higher than those in GMPP group, and the differences were statistically significant (P<0.05). ROC curve showed that the AUC values of D-dimer, lactate dehydrogenase and CRP were 0.888, 0.770 and 0.798, respectively. The sensitivity was 69.02%, 66.71% and 71.43%, respectively. The specificity was 98.73%, 85.72% and 87.01%, respectively. Conclusion The concentrations of D-dimer, lactate dehydrogenase and CRP in peripheral blood of children have certain value in predicting RMPP. The best sensitivity and specificity were CRP and D-dimer, respectively.

Key words: refractory mycoplasma pneumoniae pneumonia, children, D-dimer, lactate dehydrogenase, CRP