Abstract: Objective To explore and analysis the correlation between positive control-enhanced tran-scranial doppler (c-TCD) test and pathological features of cerebral infarction. Methods From January 2020 to April 2022, 137 patients with cerebral infarction were selected for diagnosis and treatment in the Third Affiliated Hospital of Soochow University. All patients were examined by c-TCD test, according to the determination of the microbubble signal, there were 73 cases in the positive foaming group and 64 cases in the negative foaming group.The general data, blood routine data, pathological characteristics of all patients were investigated and correlation analysis was carried out. Results In the 137 patients, there were 73 cases were positive by transcranial Doppler foaming test (positive group), accounted for 53.3%, included 40 cases of grade I, 20 cases of grade II, and 13 cases of grade III. There was no significant difference in age, body mass index, years of education and blood pressure compared between the positive group and the negative group (P>0.05). There was no significant difference in blood glucose, D-dimer, fibrinogen, platelet count and hemoglobin compared between the two groups (P>0.05). The score of the scale of paradoxical embolism (RoPE) in the positive group was significantly lower than that in the negative group, and the incidence of disease duration and family history were significantly higher than that of the foaming negative group, the differencewassignificant(P<0.05). The difference was significant in the type and location of infarction between the two groups (P<0.05). In the 73 patients, the Spearman correlation analysis showed that the positive transcranial Doppler foaming test was correlated with the course of disease, infarct type, family history, and infarct location (P<0.05). Logistic regression analysis showed that the course of disease, infarct type, family history, and infarct location were all important factors leaded to a positive transcranial Doppler bubble test (P<0.05). Conclusion Patients with cerebral infarction are often accompanied by positive transcranial Doppler foaming test, and the positive transcranial Doppler foaming test is correlated with the pathological characteristics of cerebral infarction. Therefore, in the screening of the etiology of cryptogenic cerebral infarction, Active use of transcranial Doppler foam testing is required.

Key words: Cerebral infarction, c-TCD, pathological features, correlation, paradoxical embolism scale, patent foramen ovale