The Therapeutic Effect of Low Molecular Weight Heparin Combined with Acetylcysteine in Patients with Idiopathic Interstitial Pneumonia

Abstract

Abstract: Objective To analyze the therapeutic effect of low molecular weight heparin combined with acetylcysteine in patients with idiopathic interstitial pneumonia. Methods Sixty patients with idiopathic interstitial pneumonia, who were admitted to the Department of Respiratory Medicine, Xincheng District, Zaozhuang Municipal Hospital from January 2018 to January 2021, were retrospectively selected as the study subjects, and divided into the study group and the conventional group according to different treatment methods, with 30 patients in each group. Patients in the conventional group received conventional treatment combined with low molecular weight heparin, and on the basis of the routine group, the treatment regimen of the research group was given low molecular weight heparin injection combined with acetylcysteine tablets. The adverse study and therapeutic effects were compared between the study group and the conventional group. Serum collagen type Ⅲ, HRCT lesion score, 6min walking distance, arterial partial pressure of carbon dioxide （PaCO₂）, arterial partial pressure of oxygen （PaO₂） forced vital capacity （FVC）, first second forced end-expiratory volume （FEV1）, and FEV₁/FVC were compared before and after treatment between the study group and the conventional group. Results The total effective rate of the study group was 96.67%, higher than that of the conventional group 70.00% （P<0.05）. The PaO₂ of the study group was higher than that of the conventional group, while PaCO₂ was lower than that of the conventional group （P<0.05）. After treatment, the HRCT lesion score and serum type Ⅲ collagen in the study group were lower than those in the conventional group, and the 6min walking distance was higher than that in the conventional group （P<0.05）. After treatment, patients in FEV、 FVC and FEV₁/FVC group were higher than those in conventional group （P<0.05）. The incidence of adverse reactions was 3.33% in the study group and 6.67% in the conventional group （P>0.05）. Conclusion For patients with idiopathic interstitial pneumonia, low molecular weight heparin combined with acetylcysteine can effectively improve the therapeutic effect, lung function and arterial blood gas indicators of patients are significantly improved, which is worthy of wide application.

Key words: prednisone acetate tablets, acetylcysteine, low molecular molecule heparin, idiopathic iterstitial peumonia, lung function

CLC Number:

R249

HUA Ming-lei, LIU Xiao-min, XUE Jing. The Therapeutic Effect of Low Molecular Weight Heparin Combined with Acetylcysteine in Patients with Idiopathic Interstitial Pneumonia[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(6): 1-4.

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