小青龙汤加味联合西药治疗COPD急性加重期痰湿蕴肺证的临床疗效观察

中华养生保健 ›› 2024, Vol. 42 ›› Issue (9): 7-12.

小青龙汤加味联合西药治疗COPD急性加重期痰湿蕴肺证的临床疗效观察

倪训庆¹, 张新伟², 陈祥军¹, 宋文采¹, 沈启明^3,*

1.临沂市中医医院呼吸与危重症医学科,山东临沂,276000;
2.临沂市人民医院医学影像科,山东临沂,276000;
3.临沂市中医医院心血管科,山东临沂,276000

出版日期:2024-05-01 发布日期:2024-04-23
通讯作者: ^*沈启明,E-mail：shenqm321@163.com。
作者简介:倪训庆（1985—）,女,汉族,籍贯：山东省临沂市,本科,主治中医师,研究方向：呼吸内科。
基金资助:
山东省中医药科技项目（2021Q008）

Observation on Clinical Effect of Xiaoqinglong Decoction combined with Western Medicine in Treating Phlegm-Dampness Lung Syndrome in Acute Exacerbation of COPD

NI Xun-qing¹, ZHANG Xin-wei², CHEN Xiang-jun¹, SONG Wen-cai¹, SHEN Qi-ming^3,*

1. Department of Respiratory and Critical Care Medicine, Linyi Hospital of Traditional Chinese Medicine,Shandong Linyi, 276000, China;
2. Department of Medical Imaging, Linyi People's Hospital, Shandong Linyi, 276000, China;
3. Department of Cardiology, Linyi Hospital of Traditional Chinese Medicine,Shandong Linyi, 276000, China

Online:2024-05-01 Published:2024-04-23

摘要/Abstract

摘要： 目的观察小青龙汤加味联合西药治疗慢性阻塞性肺疾病急性加重期（AECOPD）痰湿蕴肺证的临床疗效。方法选取2022年1月—2022年12月临沂市中医医院收治的AECOPD痰湿蕴肺证患者80例,按照随机数表法均分为两组,各40例。两组均用常规治疗,观察组在常规西药治疗基础上联合加味小青龙汤治疗。计算两组临床疗效,观察两组咳嗽缓解时间、气喘消失时间、哮鸣音消失时间,治疗前后血清肿瘤坏死因子-α（TNF-α）、外周血白细胞介素-6（IL-6）、超敏C反应蛋白（hs-CRP）及用力肺活量（FVC）、第一秒用力呼气量（FEV₁）、第一秒用力呼气量占用力肺活量的百分比（FEV₁/FVC）水平。结果观察组咳嗽缓解时间、气喘消失时间、哮鸣音消失时间均短于对照组,差异有统计学意义（P<0.05）。治疗后两组血清TNF-α、IL-6、hs-CRP水平较治疗前降低,且观察组低于对照组,差异有统计学意义（P<0.05）。治疗后两组肺功能FVC、FEV₁、FEV₁/FVC水平较治疗前改善,且观察组高于对照组,差异有统计学意义（P<0.05）。观察组总有效率明显优于对照组,差异有统计学意义（P<0.05）。结论小青龙汤加味治疗AECOPD痰湿蕴肺证,可以抑制炎症因子的表达,减少气道阻力,促进气道通畅,改善临床症状及肺功能,提高临床疗效。

关键词: COPD急性加重期, 痰湿蕴肺证, 小青龙汤

Abstract: Objective To observe the clinical effect of Xiaoqinglong Decoction combined with Western medicine in the treatment of phlegm-dampness lung syndrome of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 80 patients with AECOPD syndrome of phlegm-dampness and lung retention admitted to the Linyi Hospital of Traditional Chinese Medicine from January 2022 to December 2022 were selected and divided into two groups according to random number table method, 40 cases in each group. Both groups were treated with conventional treatment, and the observation group was treated with supplemented Xiaoqinglong decoction on the basis of conventional western medicine treatment. Calculate the clinical efficacy of two groups,the cough relief time, asthma disappearance time and wheezing noise disappearance time of the two groups were observed. Levels of serum tumor necrosis factor-α (TNF-α), peripheral blood interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and percentage of forced expiratory volume in the first second to forced vital capacity (FEV₁/FVC) before and after treatment. Results The cough relief time, asthma disappearance time and wheezing sound disappearance time in observation group were shorter than those in control group (P<0.05). After treatment, the serum levels of TNF-α, IL-6 and hs-CRP in the two groups were lower than before treatment, and the observation group was lower than the control group (P<0.05). After treatment, the levels of FVC, FEV₁ and FEV₁/FVC in the two groups were improved compared with those before treatment, and the observation group was higher than the control group (P<0.05). The total effective rate of the observation group was significantly better than that of the control group (P<0.05). Conclusion Xiaoqinglong Decoction can inhibit the expression of inflammatory factors, reduce airway resistance, promote airway unobstruction, improve clinical symptoms and lung function, and improve clinical efficacy in treating AECOPD syndrome of phlegm dampness and lung accumulation.

Key words: acute exacerbation of COPD, phlegm-dampness lung syndrome, Xiaoqinglong decoction

中图分类号:

R256.14

倪训庆, 张新伟, 陈祥军, 宋文采, 沈启明. 小青龙汤加味联合西药治疗COPD急性加重期痰湿蕴肺证的临床疗效观察[J]. 中华养生保健, 2024, 42(9): 7-12.

NI Xun-qing, ZHANG Xin-wei, CHEN Xiang-jun, SONG Wen-cai, SHEN Qi-ming. Observation on Clinical Effect of Xiaoqinglong Decoction combined with Western Medicine in Treating Phlegm-Dampness Lung Syndrome in Acute Exacerbation of COPD[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(9): 7-12.

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