关键词: 急性盆腔炎, 疾病严重程度, 相关性, 单核细胞趋化蛋白-1, 超敏C-反应蛋白, 分泌型免疫球蛋白A

Abstract: Objective To investigate and analysis the expression of serum secretory immunoglobulin A (sIgA), Monocyte chemoattractant protein-1 (MCP-1) and hypersensitive C-reactive protein (hs-CRP) in acute pelvic inflammation (API) and their correlation with the severity of the disease. Methods From July 2021 to May 2023, 79 cases of patients with acute pelvic inflammatory disease diagnosed and treated in a hospital were selected as the pelvic inflammatory disease group, and the other 79 cases of healthy women were selected as the health group at the same time. The contents of sIgA, MCP-1, and hs-CRP in the two groups were detected, and the disease severity of the patients were scored and analyzed. Results There was no difference in age, body mass index, years of education, heart rate, and fasting blood glucose between the two groups (P>0.05). The levels of serum monocyte chemoattractant protein-1, hypersensitive C-reactive protein, and secretory immunoglobulin A in the pelvic inflammatory disease group were significantly different from those in the healthy group (P<0.05); Logistic regression analysis showed that serum levels of secretory immunoglobulin A, monocyte chemotactic protein-1, and hypersensitive C-reactive protein were important factors affecting the disease in patients with acute pelvic inflammatory disease (P<0.05); Spearman analysis was used to demonstrate a negative correlation between disease severity scores and serum secretory immunoglobulin A levels in patients with acute pelvic inflammatory disease, and a positive correlation with monocyte chemotactic protein-1 and hypersensitive C-reactive protein levels (P<0.05). Conclusion The patients with acute pelvic inflammatory disease have a large amount of leucorrhea and obvious symptoms of lumbosacral distention and pain, which are often accompanied by high expression of serum Monocyte chemoattractant protein-1 and hypersensitive C-reactive protein, and also accompanied by low expression of serum secretory immunoglobulin A, and are related to the severity of the disease.

Key words: acute pelvic inflammatory disease, the severity of the disease, correlation, monocyte chemotactic protein-1, hypersensitivity C-reactive protein, secretory immunoglobulin A