氮卓斯汀联合疏风清热方治疗小儿过敏性结膜炎的疗效分析

摘要/Abstract

摘要： 目的研究氮卓斯汀联合疏风清热方治疗小儿过敏性结膜炎的疗效。方法选取2021年1月—2022年12月淄博市妇幼保健院收治的80例过敏性结膜炎患儿作为研究对象,采用抽签法将其随机分为对照组和观察组,各40例。对照组采用氮卓斯汀治疗,观察组在氮卓斯汀的基础上采用疏风清热方治疗。比较两组患儿的角膜荧光素染色试验（FL）评分和泪膜破裂时间（BUT）,评估两组患儿的症状评分,且检测泪液免疫球蛋白E（IgE）、嗜酸粒细胞阳离子蛋白（ECP）、白三烯B4（LTB4）和组胺（HA）水平。结果观察组的有效率明显高于对照组,差异有统计学意义（P<0.05）。治疗前,两组患儿的FL评分和BUT比较,差异无统计学意义（P>0.05）;治疗后,两组患儿的FL评分和BUT均明显改善（P<0.05）,且观察组的FL评分和BUT明显优于对照组,差异有统计学意义（P<0.05）。治疗前,两组患儿的眼痒、烧灼痛、眼睑肿胀、流泪、怕光、摩擦和异物感评分比较,差异无统计学意义（P>0.05）;治疗后,两组患儿的眼痒、烧灼痛、眼睑肿胀、流泪、怕光、摩擦和异物感评分均明显降低（P<0.05）,且观察组患儿的眼痒、烧灼痛、眼睑肿胀、流泪、怕光、摩擦和异物感评分更低,差异有统计学意义（P<0.05）。治疗前,两组患儿泪液的IgE、ECP、LTB4和HA水平比较,差异无统计学意义（P>0.05）;治疗后,两组患儿的泪液IgE、ECP、LTB4和HA水平均明显降低（P<0.05）,且观察组患儿的泪液IgE、ECP、LTB4和HA水平更低,差异有统计学意义（P<0.05）。结论氮卓斯汀联合疏风清热方治疗小儿过敏性结膜炎的疗效较佳,能明显减轻症状和促进泪膜稳定性的恢复,其机制可能与降低泪液IgE、ECP、LTB4和HA水平有关。

关键词: 氮卓斯汀, 疏风清热方, 小儿过敏性结膜炎

Abstract: Objective To study the effect mechanism of Azdrostatin combined with Shufeng Qingre formula in the treatment of pediatric allergic conjunctivitis. Methods 80 cases of patients with pediatric allergic conjunctivitis admitted to Zibo Maternal and Child Health Hospital from January 2021 to December 2022 were selected for prospective study, and were divided into two groups randomly by using lottery method. The control group was treated with Azazelastine, while the observation group was treated with Shufeng Qingre Formula on the basis of Azazelastine. The corneal fluorescein staining test (FL) score, tear film break time (BUT) , the symptom score were compared between the two groups. The tear immunoglobulin A (IgE), eosinophil cationic protein (ECP), leukotriene B4 (LTB4) and histamine (HA) levels were detected and compared between the two groups. Results The effective rate of the observation group was significantly higher than control group (P<0.05). Before treatment, there was no significant difference in FL score and BUT between the two groups (P>0.05). After treatment, the FL score and BUT of both groups were significantly improved (P<0.05), and the FL score and BUT of the observation group were significantly better (P<0.05). Before treatment, there was no significant difference in the scores of eye itching, burning pain, eyelid swelling, tearing, fear of light, friction, and foreign body sensation between the two groups (P>0.05). After treatment, the scores of the symptom above between the two groups were significantly reduced (P<0.05), and the scores of the symptom above in the observation group were lower (P<0.05). Before treatment, there was no significant difference in the levels of tear IgE, ECP, LTB4, and HA between the two groups (P>0.05). After treatment, the levels of tear IgE, ECP, LTB4, and HA in both groups were significantly reduced (P<0.05), and the levels of tear IgE, ECP, LTB4, and HA in the observation group were lower (P<0.05). Conclusion The combination of Azostatin and Shufeng Qingre Formula has a better therapeutic effect on pediatric allergic conjunctivitis, which can significantly alleviate symptoms and promote the recovery of tear film stability. Its mechanism may be related to the reduction of tear IgE, ECP, LTB4, and HA levels.

Key words: azostatin, prescription for dispersing wind and clearing heat, allergic conjunctivitis

中图分类号:

R289

韩瑛, 陈霞, 王苗, 王震, 叶壮, 杨梅, 杨艳辉, 陈莉萍. 氮卓斯汀联合疏风清热方治疗小儿过敏性结膜炎的疗效分析[J]. 中华养生保健, 2024, 42(6): 27-30.

HAN Ying, CHEN Xia, WANG Miao, WANG Zhen, YE Zhuang, YANG Mei, YANG Yan-hui, CHEN Li-ping. The Therapeutic Dffect and Mechanism of Azdrostatin Combined with Shufeng Qingre Formula in the Treatment of Pediatric Allergic Conjunctivitis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(6): 27-30.

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