刺五加注射液联合针灸对老年失眠症的治疗效果及对褪黑素、5-羟色胺水平的影响

摘要/Abstract

摘要： 目的探讨刺五加注射液联合针灸对老年失眠症的治疗效果及对褪黑素、5-羟色胺水平的影响。方法选取2020年12月—2022年12月四川省雅安市中医医院收治的80例失眠症（肝肾亏虚型）老年患者,根据随机数表法将患者分为对照组（40例）和观察组（40例）。对照组接受常规西药治疗,观察组接受刺五加注射液联合针灸治疗,对比两组睡眠障碍改善情况、褪黑素（MT）及5-羟色胺（5-HT）水平、不良情绪改变情况。结果两组治疗前睡眠时间、入睡时间、睡眠质量、睡眠效率、日间功能障碍、睡眠障碍、睡眠药物评分以及总分比较,差异无统计学意义（P>0.05）;治疗后,两组上述评分均出现不同程度降低,且观察组显著低于对照组,差异有统计学意义（P<0.05）。两组治疗前MT及5-HT水平比较,差异无统计学意义（P>0.05）;治疗后,两组MT及5-HT水平均升高,且观察组MT及5-HT水平显著高于对照组,差异有统计学意义（P<0.05）。两组治疗前焦虑自评量表（SAS）及抑郁自评量表（SDS）评分比较,差异无统计学意义（P>0.05）;治疗后,两组SAS、SDS评分均降低,且观察组SAS、SDS评分显著低于对照组,差异有统计学意义（P<0.05）。结论刺五加注射液联合针灸治疗可改善失眠症老年患者的睡眠障碍情况,提高血清MT及5-HT水平,改善患者不良情绪,值得临床应用。

关键词: 刺五加注射液, 针灸, 老年失眠症, 褪黑素, 5-羟色胺

Abstract: Objective To explore the therapeutic effect of Xiwujia injection combined with acupuncture on senile insomnia and the effects on melatonin and 5-hydroxytryptamine levels. Methods A total of 80 patients with senile insomnia (liver and kidney deficiency type) admitted to Ya 'an Hospital of Traditional Chinese Medicine in Sichuan Province from December 2020 to December 2022 were randomly divided into control group (n=40) and observation group (n=40). The control group received conventional western medicine treatment, and the observation group received Ciwujia injection combined acupuncture treatment. The improvement of sleep disorder, melatonin (MT) and 5-hydroxytryptamine (5-HT) levels and adverse mood changes were compared between the two groups. Results There were no differences in sleep time, sleep time, sleep quality, sleep efficiency, daytime dysfunction, sleep disorder, sleep medication score and total score between the two groups before treatment (P>0.05). After treatment, the above scores in both groups were decreased to different degrees, and the observation group was significantly lower than the control group (P<0.05). There were no differences in MT and 5-HT levels between the two groups before treatment (P>0.05). After treatment, the levels of the above indexes were increased in different degrees in both groups, and the observation group was significantly higher than the control group (P<0.05). There was no difference in SAS and SDS scores between the two groups before treatment (P>0.05). After treatment, the levels of the above indexes were decreased to different degrees in both groups, and the observation group was significantly lower than the control group (P<0.05). Conclusion Acanthopanax injection combined with acupuncture and moxibustion can improve the sleep disorder of elderly patients with insomnia, increase the serum MT and 5-HT levels, and improve the adverse mood of patients, it is worth applying.

Key words: acanthopanax injection, acupuncture, senile insomnia, melatonin, serotonin

中图分类号:

R592

朱双, 杨燕, 张军. 刺五加注射液联合针灸对老年失眠症的治疗效果及对褪黑素、5-羟色胺水平的影响[J]. 中华养生保健, 2024, 42(5): 29-32.

ZHU Shuang, YANG Yan, ZHANG Jun. The Therapeutic Effect of Ciwuplus Injection and Acupuncture on Senile Insomnia and Its Effect on Melatonin and Serotonin Levels[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(5): 29-32.

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