白蛋白联合光疗治疗重度新生儿高胆红素血症疗效及对TBA、TSB水平影响

摘要/Abstract

摘要： 目的探究综合运用白蛋白和光疗对治疗重度新生儿高胆红素血症的效果及对患儿总胆汁酸（total bile acid,TBA）、总胆红素（total bilirubin,TSB）水平的影响。方法选择2020年1月—2022年12月于淮安市淮阴区妇幼保健院接受临床干预的85例重度新生儿高胆红素血症的患儿为研究对象,按照其接受干预方式分为研究组（45例）和对照组（40例）。研究组联用白蛋白与光疗治疗,对照组接受单纯光疗治疗。比较两组患儿临床干预效果、干预过程中TBA、TSB等实验室指标的变化情况,并统计两组患儿治疗过程中并发症的发生情况。结果研究组患者治疗总有效率高于对照组,差异有统计学意义（P<0.05）。干预12~72 h,研究组患儿的TBA和TSB水平均低于对照组,差异有统计学意义（P<0.05）。干预前,两组患儿超敏C反应蛋白（HS-CRP）、游离脂肪酸（FFA）水平比较,差异无统计学意义（P>0.05）;干预后,研究组患儿HS-CRP、FFA水平均低于对照组,差异有统计学意义（P<0.05）。两组患儿不良反应发生率比较,差异无统计学意义（P>0.05）。结论白蛋白联合光疗对重度新生儿高胆红素血症患儿具有较好的干预效果,能够显著降低新生儿TBA及TSB水平,治疗安全性较好,值得临床应用。

关键词: 白蛋白, 光疗, 重度新生儿高胆红素血症, TBA, TSB, 水平影响

Abstract: Objective To explore the effect of comprehensive use of albumin and phototherapy on the treatment of severe neonatal hyperbilirubinemia, and quantitatively analyze the impact of intervention on total bile acid (TBA) and total bilirubin (TSB) levels in children. Methods A total of 85 children with severe neonatal hyperbilirubinemia who received clinical intervention in Huaiyin District Maternal and Child Health Hospital of Huai'an City from January 2020 to December 2022 were selected as the study subjects. According to the difference in the intervention methods, the group was divided into study group (45 cases) and control group (40 cases). The study group was treated with albumin and phototherapy, and the control group received phototherapy alone. The clinical effects of the intervention and the changes in laboratory indicators such as TBA and TSB during the intervention were compared between the two groups, the incidence of different complications in the treatment of the two groups of children was statistically analyzed. Results The total response rate of patients was higher than the control group, the difference was statistically significant (P<0.05). The levels of TBA and TSB in the study group were lower than those in the control group during the 12-72 h intervention period (P<0.05). There was no difference in the levels of HS-CRP and FFA between the two groups before intervention (P>0.05). After intervention, the levels of HS-CRP and FFA in the study group were lower than those in the control group (P<0.05). The incidence of adverse reactions in the study group and the control group were insignificant (P>0.05). Conclusion Albumin combined with phototherapy has a good intervention effect on children with severe neonatal hyperbilirubinemia, can significantly reduce the levels of TBA and TSB in newborns, and is safe for treatment, which is worthy of clinical promotion and application.

Key words: albumin, phototherapy, severe neonatal hyperbilirubinemia, TBA, TSB, horizontal impact

中图分类号:

R722

肖月红. 白蛋白联合光疗治疗重度新生儿高胆红素血症疗效及对TBA、TSB水平影响[J]. 中华养生保健, 2023, 41(21): 50-53.

XIAO Yue-hong. Effect of Albumin Combined with Phototherapy on Severe Neonatal Hyperbilirubinemia and its Influence on TBA and TSB Levels[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(21): 50-53.

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