乳腺癌保乳术后加速部分乳腺调强放疗的疗效观察

摘要/Abstract

摘要： 目的研究乳腺癌保乳术后加速部分乳腺调强放疗的疗效。方法选取2020年8月—2022年8 月邹平市中医院收治的76例乳腺癌保乳术患者为研究对象,运用随机数表法将患者分为对照组和研究组,每组38例。对照组采用常规治疗法,研究组在对照组基础上采用加速部分乳腺调强放疗法。比较两组生活健康、焦虑程度及恶性肿瘤复发转移情况。结果治疗前,两组患者卡式（KPS）评分、焦虑自评量表（SAS）评分比较,差异无统计学意义（P>0.05）;治疗后,研究组KPS评分高于对照组,SAS评分低于对照组,差异有统计学意义（P<0.05）。研究组恶性肿瘤复发转移率低于对照组,差异有统计学意义（P<0.05）。结论加速部分乳腺调强放疗可有效提高乳腺癌保乳术患者术后生活健康状况,缓解其焦虑情绪,且复发转移风险较低。

关键词: 乳腺癌保乳术, 加速部分乳腺调强放疗, 健康状况, 复发转移, 恶性肿瘤, 放射副作用

Abstract: Objective To study the effect of accelerated partial intensity-modulated radiotherapy for breast cancer after breast conserving surgery. Methods From August 2020 to August 2022, we selected breast cancer patients who received breast conserving surgery in our hospital (n=76) for research. The selected patients were divided into the control group (n=38) and the study group (n=38) by using the random number table method. The control group was treated with conventional therapy, while the research group was treated with accelerated partial breast intensity modulated radiation therapy based on the control group. The living health, anxiety level, recurrence and metastasis of malignant tumors between the two groups were compared. Results Before treatment, there was no difference between the two groups in the scores of the Self Rating Anxiety Scale (SAS) for breast cancer patients undergoing breast conserving surgery (KPS) (P>0.05); after treatment, the KPS score of the study group was higher than that of the control group, while the SAS score was lower than that of the control group (P<0.05). The recurrence and metastasis rate of malignant tumor in the study group was lower than that in the control group (P<0.05). Conclusion Accelerated IMRT for some breast cancer patients can effectively improve their health status after breast conserving surgery, alleviate their anxiety, and have a low risk of recurrence and metastasis.

Key words: breast conserving surgery for breast cancer, accelerate the intensity modulated radiotherapy of part of the breast, health, recurrence and metastasis, malignant tumor, radiation side effect

中图分类号:

王保明. 乳腺癌保乳术后加速部分乳腺调强放疗的疗效观察[J]. 中华养生保健, 2023, 41(21): 46-49.

WANG Bao-ming. Effect of Accelerated Partial Intensity Modulated Radiotherapy after Breast Conserving Surgery for Breast Cancer[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(21): 46-49.

参考文献

[1] 岳丹,白燕,李新迪,等.早期乳腺癌保乳术后加速部分乳腺调强放疗与全乳腺同步推量调强放疗的剂量学比较[J].肿瘤研究与临床,2020,32(8):546-551.
[2] MBURU W, KULASINGAM S, HODGES J S, et al.Breast-conserving surgery versus mastectomy for older women with triple-negative breast cancer:population-based study[J]. J Comp Eff Res,2022,11(13):953-967.
[3] 方涌文,邓顺坚,张俊,等.C-RAD Catalyst HD系统在乳腺癌保乳术后调强放疗中实时监测运动位移的剂量学研究[J].现代肿瘤医学,2023,31(1):144-151.
[4] 郑斯明,胡冰霜,周嘉雄,等.瘤床同步推量在早期乳腺癌保乳术后大分割容积调强放疗中的可行性及安全性[J].肿瘤研究与临床,2022,34(10):750-754.
[5] 吉维,刘梦岚,文晓博,等.左侧乳腺癌保乳术后瘤床同步推量螺旋断层放疗与容积调强放疗的剂量学研究[J].国际肿瘤学杂志,2021,48(9):532-536.
[6] 刘旭红,夏耀雄,陈晓,等.双侧乳腺癌保乳术后单射野中心与双射野中心容积旋转调强放疗的剂量学比较[J].肿瘤预防与治疗,2021,34(1):22-29.
[7] 中华医学会外科学分会乳腺外科学组.中国乳腺癌改良根治术临床实践指南(2022版)[J].中国实用外科杂志,2022,42(2):128-131.
[8] 中华医学会外科学分会乳腺外科学组.中国早期乳腺癌保乳手术临床实践指南(2022版)[J].中国实用外科杂志,2022,42(2):132-136.
[9] 李振淼,宋博,赵怡.X射线调强放疗对乳腺癌保乳术后远期生存及免疫功能影响的临床观察[J].临床肿瘤学杂志,2019,24(2):158-162.
[10] 莫月媚,叶金辉,庾海清,莫梅清,高梓扬.调强放疗与二维放疗在乳腺癌根治术后患者中的应用效果及安全性比较[J].临床医学研究与实践,2021,6(25):63-66.
[11] 中华医学会外科学分会乳腺外科学组.中国浸润性乳腺癌诊治临床实践指南(2022版)[J].中国实用外科杂志,2022,42(2):121-127.
[12] 魏敏. 乳腺癌保乳术后同步加量调强放疗的疗效观察[J].中国现代药物应用,2020,14(5):186-187.
[13] 王升晔,杜向慧,封巍,等.早期乳腺癌保乳术后全乳大分割照射同步瘤床加量与常规分割放疗的效果对比[J].中华全科医学,2019,17(8):1292-1295.
[14] 赵佳明,张娜.早期乳腺癌保乳术后加速部分乳腺照射的研究进展[J].现代肿瘤医学,2019,27(12):2215-2219.
[15] 徐晓帆,薛玉,王璐,等.术中放疗与术后放疗在早期乳腺癌保乳手术中的应用比较[J].医学研究生学报,2021,34(9):947-952.
[16] 王嘉颖,陶振洲,张树琦,曹广,骆成玉.乳腺癌保乳手术后放疗的研究进展[J].中国医药,2021,16(10):1589-1592.
[17] 陈日新,罗展雄,秦佳宁,等.早期乳腺癌保乳术后不同剂量调强放射治疗疗效比较[J].中国医学物理学杂志,2020,37(8):993-995.
[18] 罗德红,张琴,万林,等.早期乳腺癌保乳术后全乳腺放疗瘤床同期推量的大分割调强放疗与常规分割放疗的效果对比[J].慢性病学杂志,2020,21(7):986-989,993.
[19] 王波,陈存海,刘广焕,等.乳腺癌保乳术后加速部分乳腺调强放疗的疗效观察[J].中国肿瘤临床与康复,2022,29(5):605-608.
[20] 邬容,任素蓉,李雪松.调强放疗与常规放疗应用于早期左侧乳腺癌保乳术后患者的剂量学及心功能比较[J].实用医院临床杂志,2019,16(5):204-207.
[21] 赵钦,王虹伊.大分割调强放疗对乳腺癌保乳术后患者肿瘤标志物水平及预后的影响[J].临床医学研究与实践,2023,8(1):32-34.