构建“细胞自噬-气血津液-心肌缺血再灌注损伤”研究思路

中华养生保健 ›› 2023, Vol. 41 ›› Issue (12): 11-15.

构建“细胞自噬-气血津液-心肌缺血再灌注损伤”研究思路

谢延峥, 王宏伟^*

江苏医药职业学院医学院,江苏盐城,224005

发布日期:2023-06-07
通讯作者: ^*王宏伟,E-mail: 459120178@qq.com。
作者简介:谢延峥（1992—）,女,汉族,籍贯：河北省邢台市,博士研究生,讲师,研究方向：中医药防治心血管疾病。
基金资助:
江苏医药职业学院高层次引进培养人才科研基金项目（No.20216111）

Constructing the Research Idea of "Autophagy-qi, Blood and Body Fluid-myocardial Ischemia-Reperfusion Injury"

XIE Yan-zheng, WANG Hong-wei^*

Medical department, Jiangsu Vocational College of Medicine, Jiangsu Yancheng 224005, China

Published:2023-06-07

摘要/Abstract

摘要： 心肌缺血再灌注损伤（MIRI）的发生发展与气、血、津液这些物质关系密切。生理上气、血、津液为心肌细胞能量代谢的基本物质,病理上这些物质又是损伤心肌细胞功能的基本因素。随着人们对自噬的深入研究,发现自噬在缺血再灌注损伤心肌细胞中的新陈代谢作用与气血津液功能相似。自噬的失调会导致气虚气滞,自噬不足则会导致瘀血和痰饮的堆积。因此,本文通过构建“细胞自噬-气血津液-心肌缺血再灌注损伤”研究思路,从而促进中医药防治MIRI工作取得更大创新和突破。

关键词: 细胞自噬, 气血津液, 心肌缺血再灌注损伤, 研究思路

Abstract: The occurrence and development of myocardial ischemia-reperfusion injury (MIRI) is closely related to the relationship between qi, blood and body fluid. Physiologically, qi, blood, and body fluid are the basic substances for energy metabolism of myocardial cells, and pathologically, these substances are basic factors that damage the function of myocardial cells. With the in-depth study of autophagy, it was found that the metabolic role of autophagy in ischemia-reperfusion injury myocardial cells is similar to the function of qi, blood and body fluids. The imbalance of autophagy will lead to qi deficiency and stagnation, and the lack of autophagy will lead to the accumulation of blood stasis and phlegm. Therefore, this paper constructs the research idea of "autophagy-qi, blood and body fluid-myocardial ischemia-reperfusion injury", so as to promote greater innovation and breakthrough in the prevention and treatment of MIRI by traditional Chinese medicine.

Key words: autophagy, qi, blood and body fluid, myocardial ischemia-reperfusion injury, research ideas

中图分类号:

R259

谢延峥, 王宏伟. 构建“细胞自噬-气血津液-心肌缺血再灌注损伤”研究思路[J]. 中华养生保健, 2023, 41(12): 11-15.

XIE Yan-zheng, WANG Hong-wei. Constructing the Research Idea of "Autophagy-qi, Blood and Body Fluid-myocardial Ischemia-Reperfusion Injury"[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(12): 11-15.

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