灯盏生脉胶囊联合培哚普利叔丁胺治疗慢性心力衰竭的效果观察

摘要/Abstract

摘要： 目的研究灯盏生脉胶囊联合培哚普利叔丁胺对慢性心力衰竭的效果。方法选择2020年1月—2020年12月武警新疆总队医院收治的120例慢性心力衰竭患者,根据治疗方法分为对照组和观察组,每组60例。对照组单用培哚普利叔丁胺,观察组联用灯盏生脉胶囊。评估两组的心功能[左心室收缩末期内径（LVESD）、每博心输出量（SV）、左心室舒张末期内径（LVEDD）、6 min步行距离、左室射血分数（LVEF）]和症状,且检测高迁移率族蛋白 1（HMGB1）、β-内啡肽（β-EP）、可溶性糖化终末产物受体（sRAGE）、N-末端 B 型脑钠肽前体（NT-proBNP）以及转化生子因子-β1（TGF-β1）水平。结果治疗后,两组的LVESD、LVEDD明显降低,SV、6 min步行距离和LVEF均明显升高,且观察组更加明显,差异有统计学意义（P<0.05）;治疗后,两组的气喘、畏寒肢冷、心悸、气短、下肢水肿、胸闷胸痛症状评分均明显降低,且观察组更低,差异有统计学意义（P<0.05）;治疗后,两组的血清 HMGB1、sRAGE、NT-proBNP、β-EP和TGF-β1水平均明显降低,且观察组明显更低,差异有统计学意义（P<0.05）。结论灯盏生脉胶囊联合培哚普利叔丁胺可改善慢性心力衰竭患者的心功能和中医证候,降低患者的血清 HMGB1、sRAGE、NT-proBNP、β-EP和TGF-β1水平,效果显著。

关键词: 灯盏生脉胶囊, 培哚普利叔丁胺, 慢性心力衰竭, 疗效

Abstract: Objective To investigate the effect of Dengzhan Shengmai Capsule combined with perindopril tert butylamine on chronic heart failure. Methods Selected 120 cases of patients with who chronic heart failure were treated in our hospital from January 2020 to December 2020, divided into two groups according to the treatment method. The control group was treated with perindopril tert butylamine alone, and the observation group was treated with Dengzhan Shengmai Capsule. Cardiac function and symptoms were evaluated in both groups, and high mobility group1 (HMGB1), β- Endorphin（β-EP), soluble glycation end product receptor (sRAGE), N-terminal precursor of B-type brain natriuretic peptide (NT-proBNP) and transformant factor-β1（TGF-β1). Results After treatment, LVESD, SV, LVEDD, 6 min walking distance and LVEF in the two groups were significantly improved (P<0.05), and LVESD, SV, LVEDD, 6-min walking distance and LVEF in the observation group were significantly better than those in the control group (P<0.05). After treatment, the scores of asthma, palpitations, shortness of breath, edema of lower limbs, chest tightness and chest pain, and chilly cold limbs in the two groups were significantly reduced (P<0.05), and the scores of asthma, palpitations, shortness of breath, edema of lower limbs, chest tightness and chest pain, and chilly cold limbs in the observation group were significantly lower than those in the control group (P<0.05). After treatment, serum levels of HMGB1, sRAGE, NT proBNP β- EP and TGF- β 1he were significantly decreased (P<0.05). Conclusion Dengzhan Shengmai Capsule combined with perindopril tert butylamine had a significant effect in chronic heart failure, which could improve the cardiac function and TCM syndrome, and reduce the serum levels of HMGB 1, sRAGE, NT-proBNP, β -EP, and TGF- β 1.

Key words: Dengzhan Shengmai capsule, perindopril tert butylamine, chronic heart failure, curative effect

中图分类号:

R541.4

赵璇. 灯盏生脉胶囊联合培哚普利叔丁胺治疗慢性心力衰竭的效果观察[J]. 中华养生保健, 2023, 41(12): 8-11.

ZHAO Xuan. Effect of Dengzhan Shengmai Capsule Combined with Perindopril Tert Butylamine on Chronic Heart Failure[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(12): 8-11.

参考文献

[1] 郑冠群,盛晓东.沙库巴曲/缬沙坦治疗慢性心力衰竭的效果及对左心重构与超敏肌钙蛋白T水平的影响[J].中国循证心血管医学杂志,2021,13(10):1210-1213.
[2] 周坤,陈庭燕.托伐普坦治疗慢性心力衰竭的疗效及对血清TIMP-1,MMP-9水平的影响[J].心血管康复医学杂志,2021,30(1):46-50.
[3] 黄鑫涛,李之恒,史华珍.单硝酸异山梨酯联合培哚普利叔丁胺治疗慢性心力衰竭的临床研究[J].现代药物与临床,2022,37(1):90-94.
[4] 中华医学会心血管病学分会心力衰竭学组,中国医师协会心力衰竭专业委员会中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2018[J].中华心血管病杂志,2018,46(10):760.
[5] 中国中西医结合学会心血管疾病专业委员会,中国医师学会中西医结合医师分会心血管病学专家委员会.慢性心力衰竭中西医结合诊疗专家共识[J].中国中西医结合杂志,2016,36(2):133-141.
[6] 李婷婷,吕留强,赵立.老年慢性心力衰竭患者BNP,Hcy,血脂水平变化与心功能及预后的关系[J].中国循证心血管医学杂志,2021,13(9):1050-1053.
[7] 穆柏辰,昌艳艳,李东薇,等.养心定悸颗粒联合琥珀酸美托洛尔治疗慢性心力衰竭临床观察[J].中华中医药学刊,2021,39(6):232-235.
[8] 杨燕,贺小芳,刘小芸,等.芪苈强心胶囊辅助西医常规疗法治疗冠心病慢性心力衰竭系统评价[J].中国中医药信息杂志,2021,28(2):39-45.
[9] 郭娇,刘新灿,孙天福.芪参益气滴丸联合西药治疗慢性心力衰竭的临床疗效和安全性分析[J].中国循证心血管医学杂志,2020,12(5):519-524.
[10] 李娜,古丽孜热木·阿布都马那甫.比较沙库巴曲缬沙坦和缬沙坦对高血压合并慢性心力衰竭患者血管内皮功能的影响[J].河北医学,2021,27(7):1223-1227.
[11] 徐海燕,刘海浪,谷阳,等.沙库巴曲缬沙坦治疗老年射血分数减低的慢性心力衰竭患者的疗效观察[J].中华老年心脑血管病杂志,2020,22(5):479-482.
[12] 王宇,于慧卿,李永新,等.加味益气升降汤对慢性心力衰竭患者心功能及肾素-血管紧张素-醛固酮系统影响的研究[J].世界中西医结合杂志,2020,15(3):567-584.
[13] 葛迎辉,魏小云.瓜蒌薤白半夏汤加减联合比索洛尔治疗慢性心力衰竭的临床疗效[J].中西医结合心脑血管病杂志,2021,19(4):554-557.
[14] 李佳卓,张鸿婷,邹国良,等.燧心胶囊治疗慢性心力衰竭临床疗效及对患者心肌能量代谢,心脏功能的影响[J].世界中西医结合杂志,2022,17(4):806-810.
[15] 赵齐飞,彭广操,王新陆,等.炙甘草汤加减联合常规西药治疗慢性心力衰竭有效性和安全性的Meta分析[J].中药新药与临床药理,2021,32(8):1197-1205.
[16] 李卓伦,杨彦涛,孙志,等.基于UHPLC-Q-Orbitrap和网络药理学的灯盏生脉胶囊治疗心绞痛的机制研究[J].中草药,2021,52(12):3501-3513.
[17] 郭红玲,欧阳艳红,王圣,等.灯盏生脉胶囊联合单硝酸异山梨酯缓释片对老年冠心病心绞痛患者心功能,血脂及血清IL-6,CRP水平的影响[J].现代生物医学进展,2021,21(12):2373-2376,2339.
[18] 张瑞英,贾焯文,赵发利,等.血清高迁移率族蛋白B1和可溶性晚期糖基化终产物受体与心力衰竭严重程度相关性研究[J].中国循证心血管医学杂志,2020,12(3):320-323.
[19] 罗正义. 尿α_1-酸性糖蛋白,血浆N-末端脑钠肽前体在慢性心力衰竭诊断中的临床价值[J].中西医结合心脑血管病杂志,2020,18(21):3633-3635.
[20] 李雪,杨涛.灯盏生脉胶囊联合左西孟旦治疗慢性心力衰竭的临床研究[J].现代药物与临床,2022,37(7):1517-1521.