腹腔镜结肠癌根治术治疗结肠癌患者的临床效果观察

摘要/Abstract

摘要： 目的观察腹腔镜结肠癌根治术治疗结肠癌患者的临床效果。方法选择2021年4月—2023年11月张掖市第二人民医院收治的74例结直肠癌患者作为研究对象,以随机数表法将其分为对照组、观察组,各37例。对照组接受常规的开腹手术治疗,观察组接受腹腔镜结肠癌根治术治疗。比较两组血清学指标、围术期相关指标、应激反应及并发症发生情况。结果术前,两组的血清癌胚抗原（CEA）、糖类抗原125（CA125）水平比较,差异无统计学意义（P>0.05）;术后,两组的血清CEA、CA125水平均低于术前,且观察组低于对照组,差异有统计学意义（P<0.05）。观察组的术中出血量、术后引流量低于对照组,观察组的手术时间、术后排气时间、肠鸣音恢复时间、恢复饮食时间、住院时间短于对照组,差异有统计学意义（P<0.05）。术前,两组的血清肾上腺素、去甲肾上腺素、皮质醇水平比较,差异无统计学意义（P>0.05）;术后,两组的血清肾上腺素、去甲肾上腺素、皮质醇水平均高于术前,但观察组低于对照组,差异有统计学意义（P<0.05）。观察组的并发症总发生率低于对照组,差异有统计学意义（P<0.05）。结论腹腔镜结肠癌根治术治疗结肠癌患者效果确切,可促进患者康复,降低肿瘤标志物水平,减轻手术应激反应,且可降低并发症发生风险。

关键词: 腹腔镜结肠癌根治术, 结肠癌, 癌胚抗原, 糖类抗原125, 应激反应

Abstract: Objective To observe the clinical effect of laparoscopic radical resection of colon cancer in patients with colon cancer. Methods 74 patients with colorectal cancer treated in Zhangye Second People's Hospital from April 2021 to November 2023 were selected and divided into control group and observation group with 37 cases in each group by random number table method. The control group received conventional open surgery, and the observation group received laparoscopic radical resection of colon cancer. Serological indexes, perioperative related indexes, stress response and complications were compared between the two groups. Results Before operation, there was no difference in the levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125) between two groups (P>0.05). After operation, serum CEA and CA125 levels in 2 groups were lower than before operation, and observation group was lower than control group, the difference was statistically significant (P<0.05). The intraoperative blood loss and postoperative drainage volume in the observation group were lower than those in the control group, and the operation time, postoperative exhaust time, bowel sound recovery time, diet recovery time and hospital stay in the observation group were shorter than those in the control group, with statistical significance (P<0.05). Before operation, there was no difference in serum epinephrine, norepinephrine and cortisol levels between the two groups (P>0.05). After operation, the serum levels of epinephrine, norepinephrine and cortisol in 2 groups were higher than before operation, but the observation group was lower than control group, the difference was statistically significant (P<0.05). The incidence of complications in the observation group was lower than control group, and the difference was statistically significant (P<0.05). Conclusion Laparoscopic radical resection of colon cancer is effective in the treatment of colon cancer patients, which can promote the recovery of patients, reduce the level of tumor markers, reduce the stress reaction of surgery, and reduce the risk of complications.

Key words: laparoscopic radical resection of colon cancer, colon cancer, carcinoembryonic antigen, carbohydrate antigen 125, stress response

中图分类号:

R735.3

李毓. 腹腔镜结肠癌根治术治疗结肠癌患者的临床效果观察[J]. 中华养生保健, 2025, 43(7): 173-177.

LI Yu. Clinical Observation of Laparoscopic Radical Resection of Colon Cancer in Patients with Colon Cancer[J]. ZHONGHUA YANGSHENG BAOJIAN, 2025, 43(7): 173-177.

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