补肾通利汤联合ESWL治疗上尿路结石湿热蕴结证的临床研究

中华养生保健 ›› 2025, Vol. 43 ›› Issue (5): 20-24.

补肾通利汤联合ESWL治疗上尿路结石湿热蕴结证的临床研究

陈念犇^1,2, 武晶星^1,2, 胡青林^2,*

1.安徽中医药大学第一临床医学院,安徽合肥,230000;
2.安徽中医药大学附属滁州中西医结合医院泌尿外科,安徽滁州,239000

出版日期:2025-03-01 发布日期:2025-03-17
通讯作者: ^*胡青林,E-mail：zxf9120@163.com。
作者简介:陈念犇（1997—）,男,汉族,籍贯：山东省菏泽市,硕士研究生在读,医师,研究方向：中西医结合防治泌尿外科疾病研究。
基金资助:
安徽省中医药管理局重点专科建设项目（2022034）;2022年度安徽省中医药传承创新科研项目（2022CCZC15）

Clinical Study of Bushen Tongli Decoction Combined with Eswl in the Treatment of Damp-Heat Accumulation Syndrome of Upper Urinary Tract Calculi

CHEN Nian-ben^1,2, WU Jing-xing¹, HU Qing-lin^2,*

1. First Clinical Medical College, Anhui University of Chinese Medicine, Hefei Anhui, 230000, China;
2. Department of Urology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine at Chuzhou of Anhui University of Chinese Medicine, Chuzhou Anhui, 239000, China

Online:2025-03-01 Published:2025-03-17

摘要/Abstract

摘要： 目的探讨补肾通利汤联合体外冲击波碎石术（ESWL）治疗上尿路结石湿热蕴结证的临床疗效。方法本研究纳入了2023年度在安徽中医药大学附属滁州中西医结合医院受ESWL治疗的100例上尿路结石患者,采用随机数表法分为观察组与对照组,每组50例。两组均接受常规的术后处理,观察组在常规治疗的基础上加用补肾通利汤,持续至术后14 d,并对两组患者治疗效果进行比较。结果治疗后,观察组尿痛、排尿异常、腰痛、尿频证候积分均低于对照组,差异有统计学意义（P<0.05）。观察组总有效率优于对照组,差异有统计学意义（P<0.05）。观察组不良反应发生率低于对照组,差异有统计学意义（P<0.05）。两组血肌酐、血尿素氮、C反应蛋白水平均降低,且观察组以上各项指标均低于对照组,差异有统计学意义（P<0.05）。结论补肾通利汤联合ESWL治疗上尿路结石湿热蕴结证患者,可以改善症状,减轻术后相关并发症。

关键词: 补肾通利汤, 体外冲击波碎石术, 上尿路结石, 湿热蕴结

Abstract: Objective To explore the clinical efficacy of Bushen Tongli decoction combined with extracorporeal shock wave lithotripsy (ESWL) in the treatment of damp-heat accumulation syndrome of upper urinary tract calculi. Methods This study included 100 patients with upper urinary tract calculi who were treated with ESWL in Chuzhou Integrated Hospital of Anhui University of traditional Chinese Medicine in 2023. They were randomly divided into treatment group (n=50) and control group (n=50). Both groups received routine postoperative treatment, and the treatment group was treated with Bushen Tongli decoction on the basis of routine treatment until 14 days after operation, and the therapeutic effects of the two groups were compared. Results After treatment, the symptoms scores of urine pain, abnormal urination, low back pain and frequent urination in the treatment group were significantly lower than those in the control group(P<0.05). The observation group was superior to the control group in the overall effective rate(P<0.05). The adverse reactions in the treatment group was significantly lower than that in the control group(P<0.05). The levels of serum creatinine, blood urea nitrogen and C-reactive protein were decreased in both groups, and the above indexes in the treatment group were lower than those in the control group(P<0.05). Conclusion Bushen Tongli decoction combined with ESWL in the treatment of upper urinary tract calculi patients, not only improve the clinical symptoms, and improve the cure rate, showing an excellent treatment effect, is a clinical treatment method worth popularizing.

Key words: Bushen Tongli decoction, extracorporeal shock wave lithotripsy, upper urinary tract calculi, accumulation of dampness and heat

中图分类号:

R269

陈念犇, 武晶星, 胡青林. 补肾通利汤联合ESWL治疗上尿路结石湿热蕴结证的临床研究[J]. 中华养生保健, 2025, 43(5): 20-24.

CHEN Nian-ben, WU Jing-xing, HU Qing-lin. Clinical Study of Bushen Tongli Decoction Combined with Eswl in the Treatment of Damp-Heat Accumulation Syndrome of Upper Urinary Tract Calculi[J]. ZHONGHUA YANGSHENG BAOJIAN, 2025, 43(5): 20-24.

参考文献

[1] ALMERAS C, ABID N, MERIA P. lithiasis committee of the French Association of Urology (CLAFU). 2022 Recommendations of the AFU Lithiasis Committee: Extracorporeal shock wave lithotripsy (ESWL)[J].Prog Urol,2023,33(14):812-824.
[2] 罗志合,周波,王建宏,等.泌尿系结石术后组方用药规律分析[J].现代中医药,2023,43(5):118-124.
[3] 黄健,张旭.中国泌尿外科和男科疾病诊断治疗指南:2022版[M].北京:科学出版社,2022.
[4] QUHAL F, SEITZ C.Guideline of the guidelines: urolithiasis[J].Curr Opin Urol,2021,31(2):125-129.
[5] 陈红风. 中医外科学[M].北京:中国中医药出版社,2021:284-286.
[6] 中华人民共和国卫生部制定发布.中药新药临床研究指导原则[S].北京:中国医药科技出版社,1993,8:175-178.
[7] 黄慧,潘晖,钟光俊,等.急性肾绞痛致一过性肾功能受损的临床观察[J].医学新知杂志,2016,26(4):275-276.
[8] ROSENZWEIG B, PINTHUS J H, KLEINMANN N, et al.The relative contribution of urine extravasation to elevate plasma creatinine levels in acute unilateral ureteral obstruction[J].Can Urol Assoc J,2015,9(7):E428-E433.
[9] 刘玉峰,张会杰,陈海平,等.输尿管壁厚度预测肾绞痛后输尿管结石自行排出的可能性研究[J].临床泌尿外科杂志,2022,37(3):172-174,179.
[10] 张仲明. 用热淋清颗粒对接受体外冲击波碎石术的上尿路结石患者进行治疗的效果探究[J].当代医药论丛,2020,18(4):150-151.
[11] 罗昕,杨娜,童安荣.童安荣主任运用开郁行气、破血滋阴法治疗尿路结石经验[J].黑龙江中医药,2018,47(2):52.
[12] 王磊,洪正东.前列泰胶囊联合左氧氟沙星治疗湿热挟瘀型慢性前列腺炎的临床观察及其对PSA、MIP-2、VCAM-1水平的影响[J].药物评价研究,2021,44(9):1939-1944.
[13] 陈云华. 肾石通颗粒联合体外冲击波碎石治疗湿热证输尿管结石患者的临床疗效观察[J].现代诊断与治疗,2023,34(10):1442-1444.
[14] 孟虎彪,佟琳,陈广坤,等.淋证病名源流探析[J].中国中医药图书情报杂志,2024,48(2):211-214.
[15] 韩晶. 益肾通淋消石方治疗泌尿系结石(肾虚湿热型)的临床研究[D].济南:山东中医药大学,2022.
[16] 张志杰. 前列舒通胶囊联合盐酸坦索罗辛胶囊治疗经尿道前列腺切除术后患者的效果及对炎性因子水平的影响[J].中国中西医结合外科杂志,2021,27(3):447-450.
[17] 杨薇. 车前草抗氧化抗炎谱效关系研究[D].贵阳:贵州大学,2021.
[18] 隋怡,滕明刚,罗国勇,等.基于NaCl重吸收抑制作用的石韦利尿活性成分筛选[J].中草药,2021,52(4):1026-1030.
[19] ZHOU X, SUN X, GONG X, et al.Astragaloside IV from Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting inflammation via TLR4/NF-кB in vivo and in vitro[J].Int Immunopharmacol, 2017,42(11):18-24.
[20] 赵铭铭,李志明.基于五脏相关理论辨治肾性蛋白尿及应用举隅[J].中医临床研究,2023,15(33):69-73.
[21] 刘新辉,宋高峰,韦弦,等.黄芪甲苷对TGF-β1诱导下肾小管上皮细胞间充质转分化的保护作用及机制[J].江西中医药,2018,49(2):61-63.