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中华养生保健 ›› 2025, Vol. 43 ›› Issue (2): 1-4.

• 论著 •    下一篇

同型半胱氨酸联合血清miR-210-3p对急性缺血性脑卒中后认知功能障碍的预测价值分析

杨英亮1,*, 王泉亮2, 林晓青3, 孙春燕4   

  1. 1.寿光市人民医院(寿光综合医院) 神经内一科,山东 潍坊, 262700;
    2.寿光市人民医院(寿光综合医院) 神经外一科,山东 潍坊, 262700;
    3.寿光市人民医院(寿光综合医院) 新生儿科,山东 潍坊, 262700;
    4.寿光市人民医院(寿光综合医院) 影像中心,山东 潍坊, 262700
  • 出版日期:2025-01-16 发布日期:2025-01-23
  • 通讯作者: *杨英亮,E-mail：1259185669@qq.com。
  • 作者简介:杨英亮（1982—）,男,汉族,籍贯：山东省潍坊市,本科,副主任医师,研究方向：神经病学。
  • 基金资助:
    潍坊市卫生健康委员会科研项目计划（WFWSJK-2021-210）; 潍坊市卫生健康委员会科研项目计划（WFWSJK-2020-218）

Predictive Value of Homocysteine Combined with Serum miR-210-3p on Cognitive Dysfunction after Acute Ischemic Stroke

YANG Ying-liang1,*, WANG Quan-liang2, LIN Xiao-qing3, SUN Chun-yan4   

  1. 1. Shouguang people's Hospital （Shouguang General Hospital）Neurology Department I, Weifang Shandong 262700, China;
    2. Shouguang people's Hospital （Shouguang General Hospital）Neurosurgery Department I, Weifang Shandong 262700, China;
    3. Shouguang people's Hospital （Shouguang General Hospital）Division of Neonatology, Weifang Shandong 262700, China;
    4. Shouguang people's Hospital （Shouguang General Hospital）Image Center, Weifang Shandong, 262700 China
  • Online:2025-01-16 Published:2025-01-23

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摘要： 目的 分析同型半胱氨酸（Hcy）联合血清miR-210-3p在急性缺血性脑卒中患者认知功能障碍中的预测价值。方法 选择寿光市人民医院2020年7月—2023年7月收治的急性缺血性脑卒中患者97例作为研究组,对其进行蒙特利尔认知评估量表（MoCA）评估,根据其MoCA评分将其划分为认知功能障碍（PSCI）组（n=38）和非PSCI组（n=59）;并将在同一时间段来寿光市人民医院体检的健康人群100名纳入对照组。结果 研究组Hcy高于对照组,而miR-210-3p低于对照组（P<0.05）;PSCI组的Hcy高于非PSCI组,而miR-210-3p低于非PSCI组（P<0.05）;将存在组间差异有统计学意义的Hcy、miR-210-3p纳入二分类Logistic回归分析,由结果可知,miR-210-3p（OR=0.469, P<0.05）可能是急性缺血性脑卒中后认知功能障碍的独立保护因素;而Hcy（OR=25.842,P<0.05）则可能是导致急性缺血性脑卒中后认知功能障碍的危险因素。经ROC曲线分析可见Hcy、miR-210-3p及联合检测的曲线下面积分别为0.791、0.744、0.894,由大到小的排列顺序为联合检测>Hcy>miR-210-3p;其中联合检测的灵敏度为87.80%、特异性为94.10%。结论 Hcy联合miR-210-3p能很好地预测急性缺血性脑卒中后PSCI的发生情况,为临床针对性治疗提供有效的风险预测。

关键词: 同型半胱氨酸, 血清miR-210-3p, 急性缺血性脑卒中, 认知功能障碍, 预测价值

Abstract: Objective Analyze the predictive value of homocysteine (Hcy) combined with serum miR-210-3p in cognitive dysfunction of patients with acute ischemic stroke. Methods A total of 97 patients with acute ischemic stroke who received treatment in Shouguang People's Hospital from July 2020 to July 2023 were selected as the study group, and the patients were divided into cognitive dysfunction (PSCI) group (n=38) and non-PSCI group (n=59) according to the results of the Montreal Cognitive Assessment Scale (MoCA). In addition, 100 healthy people who came to our hospital for physical examination at the same phase were regarded as the control group. Results The Hcy of the study group was higher than that of the control group, while the miR-210-3p was lower than that of the control group, (P<0.05);the Hcy of the SCI group was higher than that of the non-PSCI group, and the miR-210-3p was lower than that of the non-PSCI group(P<0.05). miR-210-3p (OR=0.469, P<0.05) may be an independent protective factor for cognitive dysfunction following acute ischemic stroke; whereas Hcy (OR=25.842, P<0.05) may be a risk factor contributing to cognitive dysfunction following acute ischemic stroke. The analysis of the ROC curve shows that the areas under the curve (AUC) for Hcy, miR-210-3p, and their combined detection are 0.791, 0.744, and 0.894, respectively. The ranking from highest to lowest is: combined detection>Hcy>miR-210-3p. The sensitivity and specificity of the combined detection were 87.80% and 94.10%. Conclusion Hcy combined with miR-210-3p can predict the occurrence of PSCI after acute ischemic stroke, and provide effective risk prediction for clinical treatment.

Key words: homocysteine, serum miR-210-3p, acute ischemic stroke, cognitive dysfunction, predictive value

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