实景仿真高原红细胞增多症大鼠模型的血液学及组织器官变化

中华养生保健 ›› 2025, Vol. 43 ›› Issue (1): 1-6.

• 论著 • 下一篇

实景仿真高原红细胞增多症大鼠模型的血液学及组织器官变化

钟秉洋¹, 尹丽¹, 余伟¹, 李亚丽¹, 李康², 杨承钧¹, 钟浩^1,*

1.成都达硕实验动物有限公司研发部, 四川成都, 641421;
2.西藏自治区人民医院消化内科, 西藏拉萨, 850000

出版日期:2025-01-01 发布日期:2025-01-14
通讯作者: ^*钟浩,E-mail：zh663@163.com。
作者简介:钟秉洋（2003—）,男,汉族,籍贯：四川省成都市,本科,助理研究员,研究方向：药剂学。
基金资助:
国家自然科学基金（81960029）

Hematological and Tissue and Organ Changes in Rats with High Altitude Polycythemia

ZHONG Bing-yang¹, YIN Li¹, YU Wei¹, LI Ya-li¹, LI Kang², YANG Cheng-jun¹, ZHONG Hao^1,*

1. Research and Development Department, Chengdu Dossy Experimental Animal Co.,Ltd., Chengdu Sichuan 641421, China;
2. Department of Gastroenterology, Tibet Autonomous Region People's Hospital, Lhasa Tibet 850000, China

Online:2025-01-01 Published:2025-01-14

摘要/Abstract

摘要： 目的考察一种稳定的高原红细胞增多症（HAPC）大鼠模型的血液学及组织器官变化。方法将SD大鼠按血红蛋白值完全随机分为平原对照组和高原模型组,对照组在平原常氧下饲养,模型组置于“实景仿真高原环境人类疾病模拟系统”中饲养,实景仿真模拟海拔5 000 m的高原环境,观察大鼠的血液学及组织器官变化。结果 1周后HAPC大鼠模型成立,血红蛋白（HGB）均值达204.3 g/L,2~8周,模型组大鼠HGB均值逐渐回落;红细胞数（RBC）、红细胞比积（HCT）自2周时明显升高,持续至第6周;总蛋白（TP）和白蛋白（ALB）第2周时、尿素氮（UREA）第4周时明显升高,第8周时甘油三酯（TG）明显升高;心、肺指数自2周时明显升高,持续至第8周,肾指数第6周时明显降低,心、肺、肾均有显著病理改变。结论高原红细胞增多症大鼠1周成模,2~8周后能引起心、肺、肾等组织器官的器质性变化,8周后可见脂代谢异常。

关键词: 高原红细胞增多症, 大鼠, 高原环境模拟人类疾病动物模型饲养系统, 器质性变化

Abstract: Objective To investigate hematological and tissue-organ changes in a stable rat model of high altitude polycythemia (HAPC). Methods SD rats were completely randomly divided into plain control group and plateau model group according to hemoglobin value. The control group was raised under plain normoxia. The model group was raised in the "animal model feeding system for a plateau environment mimicking human disease”,which simulated the plateau environment at an altitude of 5 000 m, and hematology, tissue and organ changes of rats were observed. Results After 1 week, the HAPC rat model was established, and the mean HGB reached 204.3 g/L. After 2 to 8 weeks, the mean HGB of rats in the model group gradually dropped; RBC and HCT increased significantly from 2 weeks, continued to week 6;TP and ALB were significantly increased at the 2nd week, UREA at the 4th week, and triglyceride (TG) was significantly increased at the 8th week.The heart and lung index increased significantly from week 2 to week 8, and the kidney index decreased significantly at week 6, with significant pathological changes in heart, lung and kidney. Conclusions High altitude polycythemia model rats were established for 1 week,It can cause organic changes in the heart, lung, liver and kidney tissues and organs after 2-8 weeks.Abnormal lipid metabolism was observed after 8 weeks.

Key words: high altitude polycythemia, rats, animal model feeding system for a plateau environment mimicking human disease, organic changes

中图分类号:

R555.1
R-332

钟秉洋, 尹丽, 余伟, 李亚丽, 李康, 杨承钧, 钟浩. 实景仿真高原红细胞增多症大鼠模型的血液学及组织器官变化[J]. 中华养生保健, 2025, 43(1): 1-6.

ZHONG Bing-yang, YIN Li, YU Wei, LI Ya-li, LI Kang, YANG Cheng-jun, ZHONG Hao. Hematological and Tissue and Organ Changes in Rats with High Altitude Polycythemia[J]. ZHONGHUA YANGSHENG BAOJIAN, 2025, 43(1): 1-6.

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实景仿真高原红细胞增多症大鼠模型的血液学及组织器官变化

Hematological and Tissue and Organ Changes in Rats with High Altitude Polycythemia

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