舒利迭联合穴位敷贴对慢阻肺稳定期老年患者SAA水平影响

摘要/Abstract

摘要： 目的探讨舒利迭联合穴位敷贴对慢阻肺稳定期老年患者淀粉样蛋白A（SAA）水平影响。方法选取2022年6月—2022年11月白银市第一人民医院收治的200例慢性阻塞性肺疾病（COPD）稳定期老年患者作为研究对象,应用抽签法将其分为观察组（n=100）与对照组（n=100）。对照组患者应用舒利迭吸入治疗,观察组患者应用舒利迭联合穴位敷贴治疗,比较两组患者治疗前后中医证候积分水平、肺功能及SAA表达水平,并采用圣乔治呼吸问卷（SGRQ）评估治疗前后的生活质量。结果治疗后,观察组胸闷、气促、咳痰、咳嗽相关中医证候积分低于对照组,差异有统计学意义（P<0.05）;治疗后,观察组FVC、FEV₁、FEV₁/FVC、PEF高于对照组,SAA低于对照组,差异有统计学意义（P<0.05）;治疗后,观察组疾病影响、活动受限、呼吸症状及SGRQ总分低于对照组,差异有统计学意义（P<0.05）。结论舒利迭联合穴位敷贴对慢阻肺稳定期老年患者治疗效果显著,可减轻患者相关症状,提升肺功能,降低SAA表达水平,提升患者生活质量。

关键词: 舒利迭, 沙美特罗替卡松气雾剂, 穴位敷贴, 慢性阻塞性肺疾病, 稳定期, 淀粉样蛋白A

Abstract: Objective To explore the effect of Shulidie combined with acupoint application on the levels of amyloid A (SAA) in elderly patients with stable chronic obstructive pulmonary disease (COPD). Methods 200 stable elderly patients with chronic obstructive pulmonary disease (COPD) admitted to Baiyin First People's Hospital from June 2022 to November 2022 were selected as the study subjects. They were divided into an observation group and a control group using a random number table method, with 100 cases in each group. The control group patients were treated with inhalation of suletide, while the observation group patients were treated with suletide combined with acupoint application. The TCM syndrome score, lung function, and SAA expression levels of the two groups of patients were compared before and after treatment, and the quality of life before and after treatment was evaluated using the St. George's Respiratory Questionnaire (SGRQ). Results After treatment, the TCM syndrome scores related to chest tightness, shortness of breath, phlegm, and cough in the observation group were lower than those in the control group (P<0.05); After treatment, the FVC, FEV₁, FEV₁/FVC, and PEF in the observation group were higher than those in the control group, while SAA was lower than those in the control group (P<0.05); After treatment, the observation group had lower disease impact, limited activity, respiratory symptoms, and SGRQ total score than the control group (P<0.05). Conclusion The combination of Suletide and acupoint application has a significant therapeutic effect on elderly patients with stable chronic obstructive pulmonary disease, which can alleviate related symptoms, improve lung function, reduce SAA expression levels, and improve patient quality of life.

Key words: Suletide, Salmeterol and fluticasone aerosol, acupoint application, chronic obstructive pulmonary disease, stable period, Amyloid protein A

中图分类号:

R592

王琼. 舒利迭联合穴位敷贴对慢阻肺稳定期老年患者SAA水平影响[J]. 中华养生保健, 2024, 42(8): 27-30.

WANG Qiong. Effect of Shulidie Combined with Acupoint Application on SAA Levels in Elderly Patients with Stable Chronic Obstructive Pulmonary Disease[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(8): 27-30.

参考文献

[1] 冯贞贞,谢洋,李宣霖,等.慢性阻塞性肺疾病稳定期证候疗效评价量表条目权重的确定[J].世界科学技术:中医药现代化,2023,25(1):341-350.
[2] 杨发菊,华毛.稳定期慢性阻塞性肺疾病患者血管内皮功能的研究[J].临床肺科杂志,2023,28(1):30-34.
[3] 白亚虎,高胜寒,纪思禹,等.慢性阻塞性肺疾病向“前”发展[J].中国全科医学,2023,26(3):268-273.
[4] 席贝贝,武梦佳,余翠果.沙美特罗替卡松粉吸入剂对哮喘-慢性阻塞性肺疾病重叠综合征患者肺功能心率变异性及肿瘤坏死因子相关蛋白的影响分析[J].中国药物与临床,2022,22(3):238-241.
[5] 李修元,郭志洪,杨峰,等.益气温肺方穴位敷贴联合常规治疗对慢性阻塞性肺疾病急性加重患者的临床疗效[J].中成药,2023,45(3):783-787.
[6] 梁振宇,陈荣昌.慢性阻塞性肺疾病诊疗指南(2021年修订版)修订历程及思考[J].中华结核和呼吸杂志,2021,44(3):165-166.
[7] 李建生,王至婉,李素云,等.慢性阻塞性肺疾病中医证候诊断标准(讨论稿)[C]//全国中医内科肺系病第十四次学术研讨会论文集. 2010.
[8] 张巧,李红,王芹芹,等.慢性阻塞性肺疾病患者短期生活质量改变与第1秒用力呼气容积改变之间的关系研究[J].中国呼吸与危重监护杂志,2022,21(4):230-235.
[9] 高岩,赵晓倩,关艳红,等.不同剂量沙美特罗替卡松粉吸入剂对COPD患者肺功能及炎性因子的影响[J].临床误诊误治,2022,35(2):20-24.
[10] 黄绮芸,葛文逸,陈照娣,等.补中益气汤联合舒利迭治疗稳定期慢阻肺对患者mMRC及6MWT指标的影响[J].贵州医药,2022,46(7):1111-1112.
[11] 张新宇,周瑞玲,张雯,等.张琼辨治慢性阻塞性肺疾病稳定期经验[J].中国中医基础医学杂志,2023,29(2):316-319.
[12] 崔可慧,苏新明.呼出气一氧化氮检测与稳定期慢性阻塞性肺疾病患者小气道改变及预后的相关性[J].中国医科大学学报,2023,52(1):12-17.
[13] 缪冬冬,崔芳芳,张传红.急性加重期慢性阻塞性肺疾病患者SAA,MYD88及纤维蛋白原的水平及相关性[J].吉林医学,2022,43(4):878-881.
[14] 杨国庆,程佼楠.异丙托溴铵联合沙美特罗替卡松治疗慢性阻塞性肺疾病稳定期的临床效果及对患者IL-6,SAA水平的影响[J].临床医学研究与实践,2022,7(28):49-51.
[15] 杨春琦,吴崇昊,黄攀杰,等.中西医结合肺康复疗法应用于慢性阻塞性肺疾病稳定期患者的临床效果[J].中国医药,2023,18(3):1-5.