礞石滚痰丸联合阿立哌唑治疗痰火上扰型精神分裂症的疗效研究

摘要/Abstract

摘要： 目的研究礞石滚痰丸联合阿立哌唑对痰火上扰型精神分裂症的疗效。方法采用回顾性分析,选择2021年11月—2022年11月在北京市昌平区中西医结合医院接受治疗的100例痰火上扰型精神分裂症患者,根据治疗方法的不同分为对照组（52例）和观察组（48例）。对照组采用阿立哌唑治疗,观察组采用礞石滚痰丸联合阿立哌唑治疗,两组均治疗2个月。评估两组的精神症状[阳性和阴性症状量表（PANSS）]和社会功能[社会功能缺陷筛选量表（SDSS）]评分、治疗效果,且检测血清褪黑素（MT）、促甲状腺激素（TSH）和5-羟色胺（5-HT）水平。结果治疗后,两组的阴性症状、一般精神病理症状、阳性症状评分和PANSS总分均明显降低,且观察组各项评分低于对照组,差异有统计学意义（P<0.05）;观察组治疗总有效率高于对照组,差异有统计学意义（P<0.05）;治疗后,两组的社会责任心、社会活动、生活自理能力、对生活的兴趣和社会交往评分均明显降低,且观察组评分明显低于对照组,差异有统计学意义（P<0.05）;治疗后,两组的血清MT、5-HT和TSH水平均明显升高,且观察组的血清MT、5-HT和TSH水平明显高于对照组,差异有统计学意义（P<0.05）。结论礞石滚痰丸联合阿立哌唑治疗痰火上扰型精神分裂症有显著的疗效,能明显减轻精神症状,改善社会功能和血清MT、5-HT和TSH水平。

关键词: 礞石滚痰丸, 阿立哌唑, 痰火上扰型, 精神分裂症

Abstract: Objective To investigate the effect of Mengshi Guntan Pill combined with Aripiprazole in treating schizophrenia of phlegm fire upward disturbance type. Methods Using retrospective analysis, 100 patients with phlegm fire disturbance type schizophrenia who were treated in the Department of Psychiatry of Changping District Integrated Traditional Chinese and Western Medicine Hospital in Beijing from November 2021 to November 2022 were selected and divided into two groups based on different treatment methods. The control group was treated with Aripiprazole, and the observation group was treated with Mengshi Guntan Pill combined with Aripiprazole. Two groups were treated for 2 months. The mental symptoms and social function scores, treatment effects of the two groups were evaluated, and the levels of serum Melatonin (MT), Thyroid-stimulating hormone (TSH) and 5-hydroxytryptamine (5-HT) were detected. Results After treatment, the negative symptoms, general psychopathological symptoms, positive symptom scores, and total PANSS score of the two groups were significantly reduced, and the observation group was even lower (P<0.05). The total effective rate of treatment in the observation group was 97.92%, which was higher than that of 80.77% in the control group (P<0.05). After treatment, the social responsibility, social activities, self-care ability, interest in life, and social interaction scores of the two groups were significantly reduced, and the observation group were lower (P<0.05). After treatment, the levels of serum MT, 5-HT, and TSH in both groups were significantly increased, and the observation group were higher (P<0.05). Conclusion The combination of Mengshi Guntan Pill and Aripiprazole has a significant therapeutic effect on phlegm fire disturbance type schizophrenia, which can significantly alleviate mental symptoms, improve social function, and serum MT, 5-HT, and TSH levels in patients.

Key words: Mengshi Guntan Pill, Aripiprazole, phlegm fire disturbance type, schizophrenia

中图分类号:

R749.3

权涛涛, 卢宝, 于洋. 礞石滚痰丸联合阿立哌唑治疗痰火上扰型精神分裂症的疗效研究[J]. 中华养生保健, 2024, 42(7): 9-12.

QUAN Tao-tao, LU Bao, YU Yang. Clinical Study on Mengshi Guntan Pill Combined with Aripiprazole in Treating Schizophrenia of Phlegm Fire Upward Disturbance Type[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(7): 9-12.

参考文献

[1] 翁深宏,王高华,徐顺生,等.首发精神分裂症脑白质微结构异常与临床症状,认知损害及早期转归的关系[J].中华行为医学与脑科学杂志,2021,30(11):997-1004.
[2] 李娜,于振剑,张顺,等.慢性精神分裂症患者胰岛素样生长因子-1,神经细胞黏附分子水平与临床症状的相关性及对认知障碍的诊断价值[J].实用临床医药杂志,2022,26(20):62-65.
[3] 过婷,吴越,周振和.阿立哌唑与奥氮平改善慢性精神分裂症病人努力性认知,执行以及决策功能的效果比较[J].安徽医药,2022,26(3):617-621.
[4] 王清溪,赵琳,王硕.阿立哌唑联合利培酮对精神分裂症患者的疗效和不良反应观察[J].国际精神病学杂志,2022,49(1):45-47,52.
[5] 中华医学会精神医学分会.中国精神疾病分类方案及诊断标准(第3版)[M].济南:山东科学技术出版社,2002:100-101.
[6] 郑筱萸. 中药新药临床研究指导原则(第12版)[M].北京:中国医药科技出版社,2012:53-66.
[7] 朱明,宋传福.慢性精神分裂症患者血清SOD、BDNF、PANSS量表评分及临床意义[J].中国医药导报,2020,17(23):118-121.
[8] 张涛,梁毅,薛飞.阿立哌唑联合MECT治疗精神分裂症的疗效及对患者糖脂代谢、甲状腺功能及血清神经营养因子水平的影响[J].海南医学,2021,32(21):2744-2748.
[9] 周朝当,贾淑春.普建国.自编住院精神病人《社会功能评定量表》:信度、效度的初步检验[J].四川精神卫生,2004,17(3):144-146.
[10] 黄锦,朱丞.帕利哌酮缓释片联合阿立哌唑对精神分裂症精神病性症状,认知功能和催乳素的影响[J].中华全科医学,2022,20(10):1688-1690.
[11] 王珪. 泰定养生主论[M].顾宁,校注.上海:上海科学技术出版社,2014:134.
[12] 清·陈念祖.续修四库全书(子部:医家类:神农本草经读四卷)[M].上海:上海古籍出版社,2002:141.
[13] 魏·吴晋.神农本草经[M].北京:人民卫生出版社,1984:69.
[14] 陶弘景(南朝梁).本草经集注:辑校本[M].尚志钧辑校.北京:人民卫生出版社,1994:256.
[15] 沈幼丹,王龙.舒肝解郁胶囊联合礞石滚痰丸治疗精神分裂症肝郁痰结证临床研究[J].新中医,2020,52(6):47-49.
[16] 匡丹,高传霞,胥爱萍,等.自我肯定性训练对康复期住院精神分裂症患者自尊,自我效能感及心理弹性水平的干预研究[J].精神医学杂志,2022,35(3):306-310.
[17] 刘丹,孙建平,庞檬佼,等.养心安神汤对精神分裂症伴睡眠障碍患者睡眠的影响[J].实用临床医药杂志,2021,25(7):67-70.
[18] 林春燕,陈川柏,周红蕊.精神分裂症患者血清5-HT、MT、TSH水平的变化及临床意义[J].西南国防医药,2018,28(3):244-247.
[19] 房策,曾波涛.慢性精神分裂症血清非酶类抗氧化物及甲状腺激素的相关研究[J].精神医学杂志,2021,34(4):312-315.
[20] 郭向晴,赵静,易正辉,等.精神分裂症并发2型糖尿病与五羟色胺2C受体基因多态性的关联性[J].复旦学报:医学版,2021,48(1):1-7.
[21] 顾伟华,潘晓鸥,梅轶,等.清心定志汤联合奥氮平治疗精神分裂症的疗效及对血清5-HT,TSH,MT水平的影响[J].现代中西医结合杂志,2020,29(36):4057-4060.