急性心肌梗死PCI术前血清VE-Cad水平、Ang-2水平与预后的相关性分析

摘要/Abstract

摘要： 目的探讨与分析急性心肌梗死（AMI）经皮冠状动脉介入治疗（PCI）术前血清血管内皮细胞钙黏蛋白（VE-cadherin）水平、血管生成素-2（Ang-2）水平与预后的相关性。方法选择2020年3月—2022年10月在内蒙古包钢医院急诊住院的急性心肌梗死患者76例,均给予经皮冠状动脉介入治疗,在介入前检测患者的血清VE-Cad、Ang-2水平,调查与随访患者的预后主要心血管不良事件发生情况,然后进行相关性分析。结果 76例患者都随访到2023年4月1日,平均随访时间为（18.57±1.14）个月,发生主要心血管不良事件12例（观察组,未发生主要心血管不良事件归为传统组）,占15.79%,其中,再发心肌梗死3例、恶性心律失常4例、支架内血栓形成2例、血运重建1例、心力衰竭1例、心源性死亡1例。观察组的血清VE-Cad水平显著低于传统组,血清Ang-2水平显著高于传统组,差异有统计学意义（P<0.05）。Spearman相关分析显示,急性心肌梗死PCI术前血清VE-Cad水平、Ang-2水平与预后主要心血管不良事件的发生存在相关性（P<0.05）。Logistic回归分析显示,血清VE-Cad、Ang-2水平为导致急性心肌梗死PCI术后随访主要心血管不良事件发生的重要因素（P<0.05）。结论急性心肌梗死经皮冠状动脉介入后随访主要心血管不良事件发生率依然比较高,发生主要心血管不良事件的患者在术前多伴有血清VE-Cad的低表达与血清Ang-2的高表达,急性心肌梗死PCI术前血清VE-Cad水平、Ang-2水平与预后主要心血管不良事件的发生存在相关性。

关键词: 急性心肌梗死, 经皮冠状动脉介入, 主要心血管不良事件, 血管内皮细胞钙黏蛋白, 血管生成素-2, 相关性

Abstract: Objective To explore and analysis the correlation between preoperative serum levels of VE cadherin, angiopoietin-2 (Ang-2), and prognosis in patients with AMI undergoing PCI. Methods From March 2020 to October 2022,76 patients with acute myocardial infarction who were hospitalized in Inner Mongolia Baotou Steel Hospital, they were given percutaneous coronary intervention. serum VE-Cad and Ang-2 levels were tested before intervention, the prognosis of major cardiovascular adverse events in patients with follow-up was investigated, and then correlation analysis was performed. Results A total of 76 patients were followed up until April 1, 2023, with an average follow-up time of (18.57 ± 1.14) months. There were 12 cases of major cardiovascular adverse events (observation group, no major cardiovascular adverse events were classified as the traditional group) that accounted for 15.79%. Among them, 3 cases of recurrent myocardial infarction, 4 cases of malignant arrhythmia, 2 cases of stent thrombosis, 1 case of revascularization, 1 case of heart failure, and 1 case of cardiac death. The serum VE-Cad levels in the observation group were significantly lower than those in the traditional group (P<0.05), and the serum Ang-2 levels were significantly higher than those in the traditional group (P<0.05). Spearman correlation analysis showed there were correlation between pre PCI serum levels of VE-Cad and Ang-2 in patients with acute myocardial infarction and the occurrence of major cardiovascular adverse events (P<0.05). Logistic regression analysis showed that serum levels of VE-Cad and Ang-2 were important factors leading to the occurrence of major cardiovascular adverse events after PCI for acute myocardial infarction (P<0.05). Conclusion The incidence of major cardiovascular adverse events during follow-up after percutaneous coronary intervention in acute myocardial infarction is still relatively high. Patients with major cardiovascular adverse events are often accompanied by low expression of serum VE-Cad and high expression of serum Ang-2 before surgery. There are correlation between serum VE-Cad and Ang-2 levels before PCI in acute myocardial infarction and prognosis.

Key words: acute myocardial infarction, percutaneous coronary intervention, major cardiovascular adverse events, vascular endothelial cell cadherin, angiopoietin-2, relevance

中图分类号:

杨红霞. 急性心肌梗死PCI术前血清VE-Cad水平、Ang-2水平与预后的相关性分析[J]. 中华养生保健, 2024, 42(7): 37-40.

YANG Hong-xia. Correlation Analysis of Serum VE-Cad Levels, Ang-2 Levels and Prognosis before PCI for Acute Myocardial Infarction[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(7): 37-40.

参考文献

[1] 田园,潘一帆,方杭.平均血小板体积与血小板计数比值对经皮冠状动脉介入患者病情与预后评估的临床价值[J].心脑血管病防治,2023,23(1):45-48.
[2] 张静,戚瑞雪,耿俊义,等.急性心肌梗死合并室间隔穿孔患者30天内死亡风险预测模型[J].安徽医学,2023,44(1):48-52.
[3] 王志伟,王真真,刘畅,等.心肌梗死后室间隔穿孔经皮介入封堵治疗时机的选择[J].中国心血管病研究,2023,21(1):25-29.
[4] 冯品,李军,胡健强,等.QRS波终末变形与碎裂QRS波联合预测急性STEMI病人预后的价值[J].中西医结合心脑血管病杂志,2023,21(2):349-351.
[5] 程保玲,李彦宏,田艳霞.平均血小板体积/血小板计数、血小板α颗粒膜糖蛋白对经皮冠状动脉介入治疗即刻血流分级及预后的预测价值[J].安徽医药,2023,27(3):470-474.
[6] 史东星,王道清,张卉,等.CCTA技术下斑块定量分析预测冠心病患者斑块进展的价值[J].中国CT和MRI杂志,2023,21(2):73-75.
[7] 刘爱琳,王晓彤,胡月,等.SII的动态变化与PPCI术后NSTEMI患者不良临床预后的关系[J].医学研究杂志,2023,52(1):136-142.
[8] 陆杨,戎丽琳,丁超.缺铁性贫血与老年心血管疾病发生及预后的相关性[J].中国老年学杂志,2023,43(3):517-519.
[9] 高园园,郑东焕,朱莎莎.血清lncRNA MIAT表达水平与动脉瘤性蛛网膜下腔出血严重程度及预后的关系[J].检验医学与临床,2023,20(5):673-676,716.
[10] 任飞,魏腾飞,涂胜.高尿酸血症在冠状动脉非阻塞型心肌梗死预后中的预测价值[J].中华全科医学,2023,21(2):255-258.
[11] 李晓涛,黄超联,张辰浩,等.罪犯血管对行分期经皮冠状动脉介入治疗完全血运重建合并多支冠状动脉病变急性ST段抬高型心肌梗死患者预后的预测价值[J].临床内科杂志,2023,40(3):163-166.
[12] 卢厚新,郭石,杨清泉,等.术前血清学炎症指标对急性心肌梗死患者PCI术后生存时间的评价及炎症标志物构建[J].中国老年学杂志,2023,43(2):257-262.
[13] 蒋卫霞,汪浩,张凤春.急性心肌梗死短期预后与血清sST2、hs-cTnI水平的相关性[J].中国急救复苏与灾害医学杂志,2023,18(2):186-190.
[14] 张蕾,贺建勋,张琳琳,等.血清miR-208a、miR-17-5p表达与急性心肌梗死患者左心室重构和预后的关系[J].疑难病杂志,2023,22(3):247-252,265.
[15] 贺诗岚,李天亮.无创心肌做功技术在急性心肌梗死后左室重构中作用的研究进展[J].中西医结合心脑血管病杂志,2023,21(4):673-676.
[16] 柴亮听,张卉,冯艳,等.急性心肌梗死患者血清miR-423-5P,Bcl-2和LC3-II水平表达与预后相关性研究[J].现代检验医学杂志,2023,38(1):117-120,134.
[17] 苏杭,刘思丽,吴婕.急性心肌梗死并发室性心律失常及心室重构患者12导联同步心电图监测及预后分析[J].海南医学,2023,34(2):180-184.
[18] 吴小燕,吴曾繁.急性心肌梗死患者干预前后PCSK9的水平与他汀类药物治疗反应的相关性研究[J].中国心血管病研究,2023,21(2):172-176.
[19] 郭潮,刘玉琼,张慧,等.急性心肌梗死病人血清miR-30a、miR-24、miR-155水平的变化及临床意义[J].中西医结合心脑血管病杂志,2023,21(2):345-348.
[20] 丁晓云,周文杰,罗正义.急诊心肌梗死患者KV1.3-CaN-NFAT信号通路表达及预后观察[J].中国急救复苏与灾害医学杂志,2023,18(2):141-144.