麝香保心丸结合西医治疗对冠心病患者血管内皮依赖性舒张功能、血浆NO的影响

摘要/Abstract

摘要： 目的研究和分析麝香保心丸结合西医治疗对冠心病患者血管内皮依赖性舒张功能、血浆NO的影响。方法选取2021年3月—2023年3月在扶风县人民医院接受治疗的80例冠心病患者作为研究对象,随机对其进行编号,奇数设为对照组（40例）,行西医治疗;偶数设为观察组（40例）,行麝香保心丸联合西医治疗。对两组治疗效果、治疗后血管内皮舒张功能、治疗前后血浆NO浓度变化、治疗后心绞痛各项指标进行观察和比较。结果观察组治疗总有效率高于对照组,差异有统计学意义（P<0.05）。两组患者基础内径、含硝酸甘油指标比较,差异无统计学意义（P>0.05）;观察组患者反应性充血指标优于对照组,差异有统计学意义（P<0.05）。两组患者治疗前血浆NO浓度比较,差异无统计学意义（P>0.05）;治疗后,两组患者的血浆NO浓度水平均降低,并且治疗后观察组血浆NO浓度低于对照组,差异有统计学意义（P<0.05）。治疗前,两组患者心绞痛发作次数、持续时间、疼痛视觉模拟评分法（VAS）评分比较,差异无统计学意义（P>0.05）;治疗后,两组患者上述指标水平均降低,并且观察组低于对照组,差异有统计学意义（P<0.05）。结论麝香保心丸联合西医治疗对冠心病患者的治疗效果显著优于单一的西医治疗,能够促进反应性充血指数恢复,改善血管内皮依赖性舒张功能、血浆NO水平,纠正心电图异常。

关键词: 麝香保心丸, 冠心病, 血管内皮依赖性舒张, 血浆NO

Abstract: Objective To study and analyze the effect of Shexiang Baoxin Pill combined with Western medicine on endothelial dependent vasodilation function and plasma NO in patients with coronary heart disease. Methods 80 patients with coronary heart disease who received treatment from March 2021 to March 2023 in Fufeng County People's Hospital were selected as the research subjects. They were randomly numbered, and patients numbered with the odd number were set as control group (n=40), who were treated with Western medicine, while patients numbered with the even number were set as observation group (n=40), who were treated with Shexiang Baoxin Pill combined with Western medicine. Observe and compare the effect of ,treatment, vascular endothelial diastolic function after treatment, changes in plasma NO concentration before and after treatment, and various indicators of angina pectoris after treatment between the two groups. Results The total effective rate was 85.00% (34/40) in observation group and 55.00% (18/40) in control group, and the total effective rate was higher in observation group than that in control group, with statistically significant difference (P<0.05). There were no statistically significant differences in the comparison of basal internal diameter and nitroglycerin content indicators between the two groups (P>0.05). The reactive congestion index of the observation group patients was better than that of the control group, and the difference was statistically significant (P<0.05). The difference in plasma NO concentration before treatment between the two groups was not statistically significant (P> 0.05). After treatment, the plasma NO concentration levels of both groups of patients decreased, and the difference in plasma NO concentration between the observation group and the control group after treatment was statistically significant (P<0.05). There were no statistically significant differences in the number of attack of angina pectoris, duration, and visual analog score (VAS) between the two groups of patients before treatment (P>0.05). After treatment, the above indices were reduced in both groups and were lower in the observation group than in the control group, and the differences were statistically significant (P< 0.05). Conclusion The combined treatment of Shexiang Baoxin Pill and Western medicine has a significantly better therapeutic effect on patients with coronary heart disease than single Western medicine treatment. It can promote the recovery of reactive congestion index, improve endothelial dependent diastolic function, plasma NO levels, and correct electrocardiogram abnormalities.

Key words: Shexiang Baoxin pills, coronary heart disease, endothelial dependent vasodilation, plasma NO

中图分类号:

R255

白丽娜, 魏红刚. 麝香保心丸结合西医治疗对冠心病患者血管内皮依赖性舒张功能、血浆NO的影响[J]. 中华养生保健, 2024, 42(7): 26-29.

BAI Li-na, WEI Hong-gang. Effect of Shexiang Baoxin Pill Combined with Western Medicine on Endothelium-Dependent Diastolic Function and Plasma NO in Patients with Coronary Artery Disease[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(7): 26-29.

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