遵义市2021—2023年性早熟女童的昼夜自发性促性腺激素水平检测

摘要/Abstract

摘要： 目的探讨与分析2021—2023年遵义市性早熟女童的昼夜自发性促性腺激素水平检测价值。方法选择2021年9月—2023年3月在遵义市妇幼保健院诊治的78例性早熟女童作为性早熟组,同期选择在遵义市妇幼保健院进行体检的78名健康女童作为健康组。检测两组昼夜自发性促性腺激素水平、25-羟维生素D、性激素结合球蛋白含量,同时判定所有女童的卵泡生长状况。结果性早熟组子宫长径、卵巢容积、总卵泡数、最大卵泡直径都显著高于健康组（P<0.05）。性早熟组夜间自发血、日间自发血的血清促黄体生成素、促卵泡生成素含量都显著高于健康组（P<0.05）。性早熟组空腹血清25-羟维生素D、性激素结合球蛋白含量都低于健康组（P<0.05）。在78例性早熟女童中,Spearman分析显示夜间自发血、日间自发血的血清促黄体生成素、促卵泡生成素含量、子宫长径、卵巢容积、总卵泡数、最大卵泡直径、25-羟维生素D、性激素结合球蛋白与女童性早熟存在相关性（r=0.744、0.699、0.714、0.766、0.794、0.636、0.715、0.677、-0.688、-0.714,P<0.05）。结论 2021—2023年遵义市性早熟女童多表现为子宫长径、卵巢容积、总卵泡数、最大卵泡直径增加,也伴随有昼夜自发性促性腺激素水平升高与血清25-羟维生素D、性激素结合球蛋白含量降低,对性早熟女童的昼夜自发性促性腺激素水平检测具有重要的临床价值。

关键词: 遵义市, 性早熟, 昼夜自发性促性腺激素, 25-羟维生素D, 性激素结合球蛋白, 促黄体生成素

Abstract: Objective To explore and analyze the value of circadian spontaneous gonadotropin level detection in Zunyi city of girls with precocious puberty from 2021 to 2023. Methods From September 2021 to March 2023,78 cases of precocious puberty girls in Zunyi who were treated and treated in Zunyi Maternal and Child Health Hospital were selected as the precocious puberty group, and 78 cases of healthy girls who underwent physical examination in Zunyi Maternal and Child Health Hospital were selected as the health group. The levels of spontaneous Gonadotropin, 25 hydroxyvitamin D and androgen binding globulin were detected in both groups, and the follicular growth of all girls were determined. Results The uterine length diameter, ovarian volume, total follicle number, and maximum follicle diameter of the precocious puberty group were significantly higher than those of the healthy group (P<0.05). The levels of serum luteinizing hormone and follicle stimulating hormone in spontaneous blood at night and in spontaneous blood at daytime in precocious puberty group were significantly higher than those in healthy group (P<0.05). The fasting serum levels of 25 hydroxyvitamin D and androgen binding globulin in the precocious puberty group were lower than those in the healthy group (P<0.05). In 78 girls with precocious puberty, Spearman analysis showed a correlation between nighttime spontaneous blood, serum LH, OH content, uterine diameter, ovarian volume, total follicles, maximum follicle diameter, 25 hydroxyvitamin D, sex hormone-bound globulin and sex precocious puberty (r=0.744,0.699,0.714,0.766,0.794,0.636,0.715,0.677, -0.688, -0.714, P<0.05). Conclusion Zunyi 2021—2023 precocious girls with uterine long diameter, ovarian volume, total follicle number, maximum follicle diameter increase, also accompanied by increased spontaneous gonadotrophins levels and serum 25 hydroxyvitamin D, sex hormone combined with globulin content decreased, precocious girls of spontaneous spontaneous gonadotropin level detection has important clinical value.

Key words: Zunyi, precocious puberty, circadian spontaneous Gonadotropin, 25 hydroxyvitamin D, androgen binding globulin, luteinizing hormone

中图分类号:

R174

涂彬. 遵义市2021—2023年性早熟女童的昼夜自发性促性腺激素水平检测[J]. 中华养生保健, 2024, 42(6): 80-83.

TU Bin. Detection of Circadian Spontaneous Gonadotropin Levels in Girls with Precocious Puberty in Zunyi in 2021 to 2023[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(6): 80-83.

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