3D-ASL技术在高级别脑胶质瘤术后复发的价值研究

中华养生保健 ›› 2024, Vol. 42 ›› Issue (6): 164-168.

3D-ASL技术在高级别脑胶质瘤术后复发的价值研究

孟凡然¹, 王伟^1,*, 冯会玉¹, 孟少林², 何晨曦¹, 徐伟¹, 高飞¹

1.河北省涿州市医院医学影像科,河北涿州,072750;
2.河北一洲肿瘤医院放射治疗科,河北涿州,072750

出版日期:2024-03-16 发布日期:2024-03-07
通讯作者: ^*王伟,E-mail：wwmj@163.com。
作者简介:孟凡然(1987—),女,汉族,籍贯：河北省保定市,本科,主管技师,研究方向:中枢神经系统影像学。
基金资助:
保定市科技计划项目（2041ZF346）

The Value of 3D-ASL Technology in Postoperative Recurrence of High-grade Glioma

MENG Fan-ran¹, WANG Wei^1,*, FENG Hui-yu¹, MENG Shao-lin², HE Chen-xi¹, XU Wei¹, GAO Fei¹

1. Department of Medical Imaging, Zhuozhou Hospital, Zhuozhou Hebei 072750, China;
2. Department of Radiotherapy, Hebei Yizhou Cancer Hospital, Zhuozhou Heibei 072750, China

Online:2024-03-16 Published:2024-03-07

摘要/Abstract

摘要： 目的探讨三维动脉自旋标记灌注成像（3D-ASL）在高级别脑胶质瘤术后肿瘤复发的应用价值。方法回顾性分析2019年12月—2021年12月河北省涿州市医院经穿刺活检或手术病理证实的31例高级别脑胶质瘤术后复发患者作为研究对象。全部患者行磁共振平扫、增强扫描、3D-ASL检查,测量高级别脑胶质瘤术后复发区域、对侧正常脑组织脑血流量（CBF）,分为复发组CBF、正常组CBF,进行统计学分析。通过常规磁共振检查阅片与常规磁共振检查联合3D-ASL阅片分别诊断,分析诊断符合率进行统计学比较。结果高级别脑胶质瘤术后复发组CBF明显高于正常组CBF,差异有统计学意义（P<0.05）;常规磁共振检查联合3D-ASL阅片诊断高级别脑胶质瘤术后复发的诊断符合率较常规磁共振检查阅片显著提高,差异有统计学意义（P<0.05）。结论 3D-ASL技术在高级别脑胶质瘤术后复发中有较高的诊断效能,具有重要的临床应用价值。

关键词: 磁共振成像, 动脉自旋标记灌注成像, 高级别胶质瘤, 术后复发

Abstract: Objective To explore the application value of three-dimensional arterial spin labeled perfusion imaging (3D-ASL) in postoperative tumor recurrence of high-grade gliomas (HHG). Methods Retrospective analysis of 31 patients with postoperative recurrence of advanced glioblastoma in our hospital from December 2019 to December 2021. All patients underwent magnetic resonance plain scan, enhanced scan, and 3D-ASL examination to measure the recurrence area of high-grade gliomas after surgery, as well as the cerebral blood flow (CBF) of contralateral normal brain tissue, for statistical analysis. Diagnosis was made by combining conventional magnetic resonance imaging and conventional magnetic resonance imaging with 3D-ASL imaging, and the diagnostic accuracy was analyzed for statistical comparison. Results The CBF in the postoperative recurrence group of high-grade gliomas was significantly higher than that in the normal group, with a significant statistical difference (P<0.05). The diagnostic accuracy of conventional magnetic resonance imaging combined with 3D-ASL film reading in diagnosing postoperative recurrence of high-grade gliomas was significantly improved compared to conventional magnetic resonance imaging, and there was a significant statistical difference between the two (P<0.05). Conclusion 3D-ASL technology has high diagnostic efficacy in postoperative recurrence of high-grade gliomas and has important clinical application value.

Key words: magnetic resonance imaging, arterial spin labeled perfusion imaging, high-grade gliomas, postoperative recurrence

中图分类号:

R445

孟凡然, 王伟, 冯会玉, 孟少林, 何晨曦, 徐伟, 高飞. 3D-ASL技术在高级别脑胶质瘤术后复发的价值研究[J]. 中华养生保健, 2024, 42(6): 164-168.

MENG Fan-ran, WANG Wei, FENG Hui-yu, MENG Shao-lin, HE Chen-xi, XU Wei, GAO Fei. The Value of 3D-ASL Technology in Postoperative Recurrence of High-grade Glioma[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(6): 164-168.

参考文献

[1] 国家卫生健康委员会医政医管局,中国抗癌协会脑胶质瘤专业委员会,中国医师协会脑胶质瘤专业委员会.脑胶质瘤诊疗指南(2022版)[J].中华神经外科杂志,2022,38(8):757-777.
[2] 刘桂云,江蓉,徐晨阳,等.高级别脑胶质瘤综合治疗后生存分析[J].中南大学学报(医学版),2018,43(4):388-393.
[3] 《中国中枢神经系统胶质瘤诊断和治疗指南》编写组.中国中枢神经系统胶质瘤诊断与治疗指南(2015)[J].中华医学杂志,2016,96(7):485-509.
[4] 刘志强,方薪淇,宋涛,等.92例高级别胶质瘤患者术后生存分析[J].国际神经病学神经外科学杂志,2018,45(6):577-581.
[5] 潘锋,诸一吕,姚丽娣,等.3D-ASL技术在高级别脑胶质瘤术后复发诊断与鉴别诊断中的应用[J].医学影像学杂志,2018,28(8):1234-1237.
[6] 王靖雅,师毅冰.3D-ASL脑灌注成像在脑肿瘤诊断与分级中的应用价值[J].中国CT和MRI杂志,2017,15(12):4-7.
[7] 刘毛毛,贺业新.MRI预测高级别胶质瘤术后复发模式的研究进展[J].磁共振成像,2021,12(12):99-101.
[8] 林天烨,有慧,冯逢,等.动脉自旋标记MR技术进展及应用[J].中华放射学杂志,2019,53(5):431-434.
[9] 周倩,王倩倩,刘新疆.磁共振三维动脉自旋标记技术研究进展及临床应用[J].磁共振成像,2019,10(12):955-960.
[10] 马进,张翱.3D-ASL技术的研究进展及临床应用[J].国际医学放射学杂志,2015,38(1):50-53.
[11] 吴静,汪文胜,颜刘清,等.rCBFmax值对胶质瘤术前分级的价值及与MVD表达间关系的初步研究[J].磁共振成像,2018,9(6):417-421.
[12] 董卫敏,齐旭红,康群凤,等.磁共振3D-ASL与~1H-MRS对脑胶质瘤术前分级的对比研究[J].磁共振成像,2016,7(11):819-824.
[13] 陈世林,王丽英,王莉,等.3D-ASL与DSC-PWI在脑肿瘤灌注成像中的一致性分析[J].南方医科大学学报,2021,41(8):1283-1286.
[14] 周克阳,方向军,彭建春,等.1H-MRS和3D-ASL技术在脑胶质瘤分级诊断中的应用价值[J].临床放射学杂志,2022,41(7):1217-1221.
[15] 滕菲,王冀伟,殷小平,等.增强扫描结合全脑3D-ASL灌注成像在脑胶质瘤中的应用效果及对肿瘤血流量灌注指标影响分析[J].中华肿瘤防治杂志,2020,27(S1):10-12.
[16] 倪春霞,汪洋,盛晓芳,等.应用DWI和DTI勾画高级别胶质瘤术后放疗靶区的初步研究[J].临床神经外科杂志,2015,12(3):223-226.
[17] 邢振,曾峥,佘德君,等.3.0TMR多模态功能成像在胶质瘤术后复发与放射性坏死鉴别诊断中的价值[J].临床放射学杂志,2016,35(9):1309-1313.
[18] 刘志成,颜林枫,孙颖志,等.功能MRI鉴别胶质瘤术后复发及放射性脑损伤的影像学研究进展[J].磁共振成像,2017,8(9):704-710.
[19] 于秀英,任乐,刘俊杰,等.三维动脉自旋标记成像在鉴别高级别胶质瘤术后复发与假性进展的价值[J].实用放射学杂志,2021,37(2):196-198.
[20] 张雯,胡伟国,宋启斌.3D-ASL与DCE-MRI在脑胶质瘤复发与放射性脑坏死鉴别诊断中的价值[J].国际肿瘤学杂志,2021,48(10):631-634.
[21] 石慧娴,韩雷,叶靖,等.3D-ASL与DSC-PWI在高级别脑胶质瘤术后复发和放射性脑坏死鉴别诊断中的应用[J].肿瘤影像学,2020,29(3):324-329.