苓桂术甘汤加减联合醛固酮抑制剂在治疗冠心病心力衰竭中的临床观察和疗效分析

摘要/Abstract

摘要： 目的研究苓桂术甘汤加减联合醛固酮抑制剂在治疗冠心病心力衰竭患者中的临床观察和疗效。方法选择2018年1月—2022年12月洛南县中医医院收治的80例冠心病心力衰竭患者,按照随机数表法分为对照组和观察组,每组40例。对照组采用醛固酮抑制剂螺内酯治疗,观察组采用醛固酮抑制剂螺内酯联合苓桂术甘汤加减治疗。比较两组患者临床疗效及胸胁作痛、心悸、面肢浮肿、气短、面色晦暗和盗汗乏力症状评分,检测两组患者左心室收缩末期容积（LVESV）、每搏输出量（SV）、左心室舒张末期内径（LVEDD）、左心室射血分数（LVEF）、心脏指数（CI）及左心室收缩末期内径（LVESD）。结果观察组临床总有效率明显高于对照组,差异有统计学意义（P<0.05）。治疗前,两组患者胸胁作痛、心悸、面肢浮肿、气短、面色晦暗和盗汗乏力评分比较,差异无统计学意义（P>0.05）;治疗后,两组患者胸胁作痛、心悸、面肢浮肿、气短、面色晦暗和盗汗乏力评分均明显降低,且观察组胸胁作痛、心悸、面肢浮肿、气短、面色晦暗和盗汗乏力评分低于对照组,差异有统计学意义（P<0.05）。治疗前,两组患者LVESV、SV、LVEDD、LVEF、CI和LVESD比较,差异无统计学意义（P>0.05）;治疗后,两组患者LVESV、SV、LVEDD、LVEF、CI和LVESD均明显改善,且观察组的LVESV、SV、LVEDD、LVEF、CI和LVESD明显优于对照组,差异有统计学意义（P<0.05）。结论苓桂术甘汤加减联合醛固酮抑制剂螺内酯对冠心病心力衰竭患者有显著的疗效,能明显减轻症状,改善心功能。

关键词: 苓桂术甘汤加减, 醛固酮抑制剂, 冠心病, 心力衰竭

Abstract: Objective To study the effect of Linggui Zhugan decoction combined with aldosterone inhibitors in the treatment of coronary heart disease and heart failure. Methods Selected 80 cases of patients with coronary heart disease and heart failure from January 2018 to December 2022, divided into two groups randomly. The control group was treated with aldosterone inhibitor spironolactone, while the observation group was treated with Linggui Zhugan decoction. The symptom scores of chest and hypochondriac pain, palpitations, facial edema, shortness of breath, dark complexion and night sweating fatigue in the two groups were evaluated, and the left ventricular end systolic volume (LVESV), stroke volume (SV), left ventricular end diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), cardiac index (CI) and left ventricular end systolic diameter (LVESD) in the two groups were measured. Results The effective rate of the observation group was significantly higher than control group (P<0.05). Before treatment, there was no significant difference in the scores of chest and hypochondriac pain, palpitations, facial limb edema, shortness of breath, dark complexion, and night sweating fatigue between the two groups (P>0.05). After treatment, the scores of chest and hypochondriac pain, palpitations, facial limb edema, shortness of breath, dark complexion, and night sweating fatigue in the two groups were significantly reduced (P<0.05), and the scores of chest and hypochondriac pain, palpitations, facial limb edema, shortness of breath, dark complexion, and night sweating fatigue in the observation group were lower (P<0.05). Before treatment, there was no significant difference in LVESV, SV, LVEDD, LVEF, CI, and LVESD between the two groups (P>0.05). After treatment, the LVESV, SV, LVEDD, LVEF, CI, and LVESD of the two groups were significantly improved (P<0.05), and the LVESV, SV, LVEDD, LVEF, CI, and LVESD of the observation group were significantly better than those of the control group (P<0.05). Conclusion Linggui Zhugan Tang combined with aldosterone inhibitor spironolactone has a significant therapeutic effect on patients with coronary heart disease and heart failure, which can significantly alleviate symptoms and improve heart function.

Key words: Linggui Zhugan Tang, aldosterone inhibitors, coronary heart disease, heart failure

中图分类号:

R541

白冰, 赵永强. 苓桂术甘汤加减联合醛固酮抑制剂在治疗冠心病心力衰竭中的临床观察和疗效分析[J]. 中华养生保健, 2024, 42(5): 37-39.

BAI Bing, ZHAO Yong-qiang. Clinical Observation and Therapeutic Analysis of Linggui Zhugan Decoction Combined with Aldosterone Inhibitors in the Treatment of Coron[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(5): 37-39.

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