阿司匹林对不同孕周子痫前期高风险孕妇的疗效比较

摘要/Abstract

摘要： 目的比较分析阿司匹林在不同孕周对子痫前期高风险孕妇干预后的疗效,为提高妊娠安全性提供参考。方法择取2019年9月—2022年9月在南通大学附属江阴医院接受治疗的80例子痫前期高风险孕妇作为研究对象,随机将其分成A组（n=28）、B组（n=28）、空白对照组（n=24,未服用阿司匹林）。A组患者自妊娠12周服用100 mg阿司匹林,B组患者自妊娠16周服用100 mg阿司匹林,两组妊娠28周时停药,控制血压为130~155/80~105 mm Hg,若并发脏器功能障碍,则控制为130~139/80~89 mm Hg,比较三组子痫前期发生情况与妊娠结局、分娩方式、新生儿相关结局、尿液错误折叠蛋白阳性率。结果 A组与B组子痫前期、不良妊娠结局发生率比较,差异无统计学意义（P>0.05）;A组、B组子痫前期、不良妊娠结局发生率较对照组低,差异有统计学意义（P<0.05）。A组与B组剖宫产率、顺产率比较,差异无统计学意义（P>0.05）;A组、B组剖宫产率低于对照组,顺产率高于对照组,差异有统计学意义（P<0.05）。A组与B组新生儿Apgar评分、新生儿不良结局发生率比较,差异无统计学意义（P>0.05）;A组、B组新生儿Apgar评分高于对照组,新生儿不良结局发生率低于对照组,差异有统计学意义（P<0.05）。A组孕28周、32周的尿液错误折叠蛋白阳性率均显著低于对照组,且A组阳性率低于B组,差异有统计学意义（P<0.05）。结论阿司匹林在预防子痫前期中具有显著效果,高风险孕妇在妊娠12周及16周时服用阿司匹林均可有效降低子痫前期发生率,同时还可提高顺产率,降低母婴不良结局发生率。

关键词: 阿司匹林, 不同孕周, 子痫前期, 高风险孕妇

Abstract: Objective To compare and analyze the efficacy of aspirin in different gestational weeks on high-risk pregnant women with preeclampsia, and to provide reference for pregnancy safety. Methods Eighty pregnant women with high risk of preeclampsia who received treatment in the department of obstetrics,Jiangyin Hospital Affiliated to Nantong University from September 2019 to September 2022 were selected as the main body and randomly divided into group A (28 cases), Group B (28 cases) and blank control group (24 cases, without taking aspirin). Patients in group A received 100 mg aspirin since the 12th week of gestation, and patients in group B received 100 mg aspirin since the 16th week of gestation. The drug was stopped at the 28th week of gestation in both groups, and the blood pressure control was 130-155/80-105mmHg. If the complication was organ dysfunction, the control was 130-139/80-89mmHg. Preeclampsia occurrence, pregnancy outcome, mode of delivery, neonatal related outcome and urine misfolded protein positive rate were compared among the three groups. Results There was no significant difference in the incidence of preeclampsia and adverse pregnancy outcomes between Group A and Group B (P>0.05); The incidence of preeclampsia and adverse pregnancy outcomes in Group A and Group B was lower than that in the control group(P<0.05). There was no significant difference in cesarean section rate and spontaneous labor rate between Group A and Group B (P>0.05); The cesarean section rate in Group A and Group B was lower than that in the control group, and the spontaneous delivery rate was higher than that in the control group (P<0.05). There was no significant difference in Apgar score and incidence of adverse neonatal outcomes between Group A and Group B (P>0.05); The Apgar of newborns in Group A and Group B was higher than that in the control group, and the incidence of adverse neonatal outcomes was lower than that in the control group (P<0.05). Urine misfolded protein positive rates in group A at 28 weeks and 32 weeks of pregnancy were significantly lower than those in control group, and the positive rate in group A was lower than that in group B (P<0.05). Conclusion Aspirin has a significant effect in the prevention of preeclampsia. Taking aspirin at 12 and 16 weeks of gestation in high-risk pregnant women can effectively reduce the incidence of preeclampsia, while also improving the rate of spontaneous labor and reducing the incidence of adverse maternal and infant outcomes.

Key words: aspirin, different gestational weeks, preeclampsia, high-risk pregnant women

中图分类号:

R714.2

梅吉. 阿司匹林对不同孕周子痫前期高风险孕妇的疗效比较[J]. 中华养生保健, 2024, 42(4): 43-46.

MEI Ji. Comparison of Therapeutic Effects of Aspirin on High-risk Pregnant Women with Preeclampsia at Different Gestational Weeks[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(4): 43-46.

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