化浊行血汤联合常规治疗对原发性高脂血症患者血脂及超敏C反应蛋白影响的研究

摘要/Abstract

摘要： 目的研究分析化浊行血汤联合常规治疗对原发性高脂血症患者血脂及超敏C反应蛋白（hs-CRP）的影响。方法选取2021年6月—2022年5月潍坊市中医院收治的80例原发性高脂血症患者作为研究对象,按照随机数表法分为对照组（n=40）和观察组（n=40）,对照组患者给予常规治疗方案,观察组患者给予常规治疗联合化浊行血汤方案。比较两组患者治疗前后总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、超敏C反应蛋白（hs-CRP）指标水平。评定并比较两组患者治疗前后形体肥胖、头重如裹、肢体怠惰等中医证侯积分。结果治疗前,两组患者血脂水平比较,差异无统计学意义（P>0.05）;治疗后,观察组TC、TG、LDL-C水平低于对照组,HDL-C水平明显高于对照组,差异有统计学意义（P<0.05）。两组患者治疗前hs-CRP水平比较,差异无统计学意义（P>0.05）;治疗后,观察组hs-CRP水平明显低于对照组,差异有统计学意义（P<0.05）。两组患者治疗前形体肥胖、头重如裹、肢体怠惰积分比较,差异无统计学意义（P>0.05）;治疗后,观察组上述证候积分明显低于对照组,差异有统计学意义（P<0.05）。结论对原发性高脂血症患者给予常规治疗联合化浊行血汤方案,可有效改善血脂代谢异常,减轻机体炎性反应,缓解患者中医证候,值得临床应用。

关键词: 化浊行血汤, 原发性高脂血症, 血脂代谢, 超敏C反应蛋白, 中医证候积分

Abstract: Objective To study the effect of combined treatment with Huazhuoxingxue Decoction on lipid metabolism and serum high-sensitivity C-reactive protein (hs-CRP) in patients with primary hyperlipidemia. Methods A total of 80 patients with primary hyperlipidemia were selected from June 2021 to May 2022 in Weifang Hospital of Traditional Chinese Medicine. Using the random number table method, they were divided into a control group (40 cases) and an observation group (40 cases). Patients in the control group received routine treatment, while those in the observation group received routine treatment combined with Huazhuoxingxue Decoction. The levels of total cholesterol(TC), triglyceride(TG), high density lipid-cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), and hs-CRP before and after treatment were compared between the two groups. The TCM syndrome scores of obesity, drowsiness, and physical laziness before and after treatment were evaluated and compared between the two groups. Results Before treatment, there was no difference in the levels of blood lipid level between the two groups ( P>0.05). Following treatment, the levels of TC, TG, and LDL-C in the observation group were lower than those in the control group, while the level of HDL-C was significantly higher than that in the control group(P<0.05). Prior to treatment, there was no difference in the levels of hs-CRP between the two groups(P>0.05). Following treatment, the level of hs-CRP in the observation group was significantly lower than that in the control group(P<0.05). Before treatment, there was no difference in the TCM syndrome scores of obesity, drowsiness, and physical laziness between the two groups(P> 0.05). After treatment, the TCM syndrome scores of obesity, drowsiness, and the levels of physical laziness in the observation group were significantly lower than those in the control group(P<0.05). Conclusion Routine treatment combined with Huazhuoxingxue Decoction can effectively improve lipid metabolism disorder and reduce systemic inflammation response, thereby relieving TCM syndrome and is worth promoting for patients with primary hyperlipidemia.

Key words: Huazhuoxingxue decoction, primary hyperlipidemia, lipid metabolism, hypersensitive C-reactive protein, TCM syndrome score

中图分类号:

R285.6

付登磊, 周晓娟, 邵娜, 曲雪东. 化浊行血汤联合常规治疗对原发性高脂血症患者血脂及超敏C反应蛋白影响的研究[J]. 中华养生保健, 2024, 42(4): 32-35.

FU Deng-lei, ZHOU Xiao-juan, SHAO Na, QU Xue-dong. The Study of the Effect of Huazhuxingxue Decoction Combined with Routine Treatment on Lipid and Supersensitized C-Reactive Protein in Primary Hyperlipidemia Patients[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(4): 32-35.

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