关键词: 总胆汁酸, 前列腺素E2, 早期消化道出血, 灵敏度, 特异度

Abstract: Objective To investigate the diagnostic value of total bile acid (TBA) combined with prostaglandin E2 (PGE2) in early gastrointestinal bleeding. Methods From July 2018 to July 2023, 105 cases of patients with gastrointestinal bleeding in Beijing Changping District Hospital of Integrative Medicine were retrospectively analyzed. All patients were diagnosed by gastroscopy. Patients were grouped according to the amount of bleeding. Patients with a bleeding volume of<500 mL were divided into a mild group (n=40), patients with a bleeding volume of 800-1000 mL were divided into a moderate group (n=25), and patients with a bleeding volume of>1500mL were divided into a severe group (n=10). Another 40 healthy people who came to our hospital for physical examination during the same period were selected as the control group. The expression levels of TBA and PGE2 in the four groups were compared, and the correlation between TBA and PGE2 and the severity of gastrointestinal bleeding was analyzed. The receiver operating characteristic (ROC) curve was established to analyze the diagnostic threshold of TBA and PGE2 for early gastrointestinal bleeding. Results The expression levels of TBA and PGE2 in the severe group higher than those in the moderate group, mild group and control group, and the level of PGE2 was significantly lower than those in the moderate group, mild group and control group (P<0.05); Spearman correlation analysis showed that TBA was positively correlated with the severity of gastrointestinal bleeding (P<0.05), while PGE2 was negatively correlated with the severity of gastrointestinal bleeding (P<0.05); The critical value of TBA is 11.32 μ The diagnostic index reached the maximum value of 1.678 at the concentration of 1.678 mol/L. the sensitivity and specificity for the diagnosis of early gastrointestinal bleeding were 81.27% and 79.46%, respectively. When the critical value of PGE2 was 95.26 pg/mL, the diagnostic index reached the maximum value of 1.689, and the sensitivity and specificity for the diagnosis of early gastrointestinal bleeding were 84.95% and 81.26%, respectively. Conclusion TBA combined with PGE2 detection plays a positive role in improving the diagnosis rate of early gastrointestinal bleeding, and is correlated with the severity of gastrointestinal bleeding μ 26 pg/ml, and timely take relevant measures for intervention.

Key words: total bile acids, Prostaglandin E2, early gastrointestinal bleeding, sensitivity, specificity