探讨一清胶囊联合维胺酯胶囊治疗口腔扁平苔藓的临床疗效及安全性

中华养生保健 ›› 2024, Vol. 42 ›› Issue (22): 15-18.

探讨一清胶囊联合维胺酯胶囊治疗口腔扁平苔藓的临床疗效及安全性

徐道慧¹, 赵静², 逄蕾^1,*, 赵鹏¹

1.同济大学附属东方医院胶州医院口腔科,山东青岛,266300;
2.胶州市妇幼保健计划生育服务中心中医科,山东青岛,266300

出版日期:2024-11-16 发布日期:2024-11-13
通讯作者: ^*逄蕾,E-mail：2365314662@qq.com。
作者简介:徐道慧（1971—）,男,汉族,籍贯：山东省胶州市,本科,副主任医师,研究方向：口腔内科。

Exploring the Clinical Efficacy and Safety of Yiqing Capsules Combined with Vitamin B Capsules in the Treatment of Oral Lichen Planus

XU Dao-hui¹, ZHAO Jing², PANG Lei^1,*, ZHAO Peng¹

1. Department of Stomatology, Jiaozhou Hospital, Dongfang Hospital Affiliated to Tongji University, Qingdao Shandong 266300, China;
2. Traditional Chinese Medicine Department of Jiaozhou Maternal and Child Health and Family Planning Service Center, Qingdao Shandong 266300, China

Online:2024-11-16 Published:2024-11-13

摘要/Abstract

摘要： 目的探究与分析一清胶囊联合维胺酯胶囊治疗口腔扁平苔藓的临床疗效及安全性。方法选择2020年4月—2024年2月同济大学附属东方医院收治的238例扁平苔癣患者作为研究对象,依据随机数表法将其分为对照组和观察组,各119例,对照组采取维胺酯胶囊治疗,观察组在对照组治疗基础上联合一清胶囊治疗,两组均连续治疗3个月,比较两组疗效、疼痛程度、病损面积及炎症反应、不良反应发生情况。结果观察组临床总有效率高于对照组,差异有统计学意义（P<0.05）;治疗后观察组VAS评分低于对照组,病损面积小于对照组,差异有统计学意义（P<0.05）;观察组血清SP、IL-8及IL-12水平低于对照组,差异有统计学意义（P<0.05）;两组不良反应发生率比较,差异无统计学意义（P>0.05）。结论实施一清胶囊联合维胺酯胶囊的联合用药方案治疗口腔扁平苔癣表现出了更高的临床总有效率,可促进调节及改善患者的症状及体征,减轻疾病造成的疼痛感,缩小病损部位,同时在治疗期间还可调节血清SP、IL-8及IL-12水平,获得更好的预后,整体安全性也较高。

关键词: 一清胶囊, 维胺酯胶囊, 口腔扁平苔藓, 疗效, 安全性

Abstract: Objective To explore and analyze the clinical efficacy and safety of Yiqing Capsules combined with Viamine Capsules in the treatment of oral lichen planus. Methods A random number table method was used to group 238 cases of lichen planus admitted to Department of Stomatology, Jiaozhou Hospital from April 2020 to February 2024, with 119 cases in each group. The control group was treated with vitamin E capsules, while the observation group was treated with Yiqing capsules. The two groups were treated continuously for 3 months. The efficacy, pain degree, lesion area and inflammatory response were compared between the two groups, and the adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group. Compared with the control group after treatment, the VAS score of observation group was lower, the lesion area was reduced, and the serum levels of SP, IL-8 and IL-12 were lower, with statistical significance (P<0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). Conclusion The combination of Yiqing capsule and viaminate capsule showed a higher clinical total effective rate of oral lichen planus, which can promote the regulation and improvement of symptoms and signs of patients, reduce the pain caused by the disease, shrink the lesion site, and also regulate the levels of serum SP, IL-8 and IL-12 during treatment, so as to obtain a better prognosis. The overall security is also high.

Key words: Yiqing Capsules, Vitamin ester capsules, oral lichen planus, therapeutic effect, security

中图分类号:

R781.5

徐道慧, 赵静, 逄蕾, 赵鹏. 探讨一清胶囊联合维胺酯胶囊治疗口腔扁平苔藓的临床疗效及安全性[J]. 中华养生保健, 2024, 42(22): 15-18.

XU Dao-hui, ZHAO Jing, PANG Lei, ZHAO Peng. Exploring the Clinical Efficacy and Safety of Yiqing Capsules Combined with Vitamin B Capsules in the Treatment of Oral Lichen Planus[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(22): 15-18.

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