成人特发性膜性肾病中血清PLA2R联合IgG4的检测的临床效果评价

摘要/Abstract

摘要： 目的对血清M型磷酸酯酶A2受体（PLA2R）联合肾组织IgG4的在成人特发性膜性肾病中的表达水平进行早期检查诊断,同时探讨其影响意义。方法选取2020年5月—2022年5月青岛市市北区老年病医院（青岛市市北区人民医院）收治的成人特发性膜性肾病患者42例作为观察组,同时选取同期收治的肾脏疾病微小病变患者34例作为对照组A及膜性狼疮性肾炎患者30例作为对照组B,采用环孢素A联合糖皮质激素对观察组进行治疗,比较几组患者的血清M型磷酸酯酶A2受体（PLA2R）联合肾组织IgG4的检测水平。结果三组患者的性别、年龄、病程、24 h尿蛋白、血清清蛋白、血肌酐及血尿素水平比较,差异均无统计学意义（P>0.05）。与对照组A、对照组B比较,观察组PLA2R测量值、肾组织IgG4测定结果阳性率均较高,差异均有统计学意义（P<0.05）。对照组A、对照组B的PLA2R、肾组织IgG4测定结果比较,差异无统计学意义（P>0.05）。观察组治疗后与治疗前比较,PLA2R测量值较低,差异有统计学意义（P<0.05）。结论血清M型磷酸酯酶A2受体（PLA2R）与肾组织IgG4在成人特发性膜性肾病患者中可呈现出异常的表达水平,与健康人群和膜性狼疮肾炎患者可表现出明显的差异性,能够为疾病的判断提供参考依据。

关键词: 血清M型磷酸酯酶A2受体, 肾组织IgG4, 成人特发性膜性肾病

Abstract: Objective To investigate the early detection and diagnosis of the expression levels of serum M-type phosphatase A2 receptor (PLA2R) combined with renal tissue IgG4 in adult idiopathic membranous nephropathy, and to explore its significance. MethodForty-two adult patients with idiopathic membranous nephropathy admitted to Qingdao Shibei District Geriatric Hospital (Qingdao Shibei District People's Hospital) from May 2020 to May 2022 were selected as the observation group, while 34 patients with minimal lesions of kidney disease admitted during the same period were selected as control group A and 30 patients with membranous nephropathy were selected as control group B. The observation group was treated with cyclosporin A combined with glucocorticoid. The serum M-type phosphatase A2 receptor (PLA2R) and renal tissue IgG4 levels were compared in several groups of patients. ResultThere were no significant differences in gender, age, disease duration, 24-hour urine protein, serum albumin, blood creatinine, and blood urea levels among the three groups of patients (P>0.05). Compared with control group A and control group B, the observation group had higher PLA2R measurement values and higher positive rates of IgG4 measurement in renal tissue. The difference between the groups was statistically significant (P<0.05). There was no statistically significant difference (P>0.05) in the measurement results of BPLA2R and IgG4 in renal tissue between control group A and control group. The PLA2R measurement value in the observation group was lower after treatment compared to before treatment, and the difference between the groups was statistically significant (P<0.05). Conclusions erum M-type phosphatase A2 receptor (PLA2R) and renal tissue IgG4 show abnormal expression levels in adult patients with idiopathic membranous nephropathy, which is significantly different from that in healthy people and membranous lupus nephritis, which can provide reference for the diagnosis of the disease.

Key words: serum M-type phosphatase A2 receptor, IgG4 in renal tissue, adult idiopathic membranous nephropathy

中图分类号:

R692

鲍美燕, 纪琰昕. 成人特发性膜性肾病中血清PLA2R联合IgG4的检测的临床效果评价[J]. 中华养生保健, 2024, 42(19): 170-173.

BAO Mei-yan, JI Yan-xin. Clinical Efficacy Evaluation of Serum PLA2R Combined with IgG4 Detection in Adult Idiopathic Membranous Nephropathy[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(19): 170-173.

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