高频振荡通气联合布地奈德治疗毛细支气管炎危重患儿的近期与长期预后效果分析

摘要/Abstract

摘要： 目的探讨与分析高频振荡通气联合布地奈德治疗毛细支气管炎危重患儿的近期与长期预后效果。方法选择2018年2月—2020年7月在岐山县医院诊治的74例毛细支气管炎危重患儿作为研究对象,根据1:1随机数表法把患儿分为高频振荡通气组与对照组,各37例。对照组给予布地奈德治疗,高频振荡通气组在对照组治疗的基础上给予高频振荡通气治疗,两组都连续治疗7 d,观察与随访所有患儿的近期与长期预后。结果治疗后高频振荡通气组的近期总有效率为97.30%,与对照组的83.78%相比有显著提高（P<0.05）。高频振荡通气组治疗期间的气胸、感染、恶心呕吐、静脉血栓等不良反应发生率为5.41%,显著低于对照组的27.03%（P<0.05）。两组治疗后的潮气量、吸呼比均明显高于治疗前,治疗后高频振荡通气组明显高于对照组（P<0.05）。治疗后高频振荡通气组与对照组的儿童生存质量普适性核心量表（PedsQLTM）评分均明显高于治疗前（P<0.05）,治疗后高频振荡通气组也明显高于对照组（P<0.05）。治疗后随访2年,高频振荡通气组的复发率为2.70%,与对照组的18.92%相比显著降低（P<0.05）。结论高频振荡通气联合布地奈德治疗毛细支气管炎危重患儿能提高近期治疗效果,减少不良反应的发生,也能提高患儿的肺功能与生活质量,减少远期复发率。

关键词: 高频振荡通气, 布地奈德, 毛细支气管炎, 不良反应, 肺功能, 生活质量, 复发率

Abstract: Objective To investigate and analysis the short-term and long-term prognostic effects of high-frequency oscillatory ventilation combined with budesonide in the treatment of critically ill children with bronchiolitis. Methods From February 2018 to July 2020, 74 critically ill children with bronchiolitis who were diagnosed and treated in our hospital were selected. Accorded to the 1:1 random number table method, the children were divided into the high-frequency oscillatory ventilation group and the control group with 37 cases in each group. The control group were treated with budesonide, and the high-frequency oscillatory ventilation group were treated with high-frequency oscillatory ventilation based on the treatment of the control group. The two groups received continuous treatment for 7 days. The short-term and long-term prognosis of all children were observed and followed up. Results After treatment, the short-term total effective rates of the high-frequency oscillatory ventilation group were 97.30%, which were significantly higher than 83.78% of the control group(P<0.05). The incidence rates of adverse reactions such as pneumothorax, infection, nausea and vomiting, and venous thrombosis in the high-frequency oscillatory ventilation group during treatment were 5.41%, which were significantly lower than that in the control group 27.03%(P<0.05). The tidal volume, inhalation to exhalation ratio after treatment in the two groups were significantly higher than those before treatment, and the high-frequency oscillatory ventilation group were also significantly higher than the control group after treatment (P<0.05). After treatment, the PedsQLTM quality of life scores in both the high-frequency oscillatory ventilation group and the control group were significantly higher than those before treatment (P<0.05), and the high-frequency oscillatory ventilation group after treatment were also significantly higher than the control group (P<0.05). During the 2-year followed-up after treatment, the recurrence rate in the high-frequency oscillatory ventilation group were 2.70%, which were significantly lower than 18.92% in the control group(P<0.05). Conclusion High-frequency oscillatory ventilation combined with budesonide in the treatment of critically ill children with bronchiolitis can improve the short-term treatment effect, reduce the occurrence of adverse reactions, improve the children's pulmonary function and quality of life, and reduce the long-term recurrence rate.

Key words: high-frequency oscillatory ventilation, budesonide, bronchiolitis, adverse reactions, pulmonary function, quality of life, recurrence rate

中图分类号:

刘小花. 高频振荡通气联合布地奈德治疗毛细支气管炎危重患儿的近期与长期预后效果分析[J]. 中华养生保健, 2024, 42(18): 170-173.

LIU Xiao-hua. Short-Term and Long-Term Prognosis of High-Frequency Oscillatory Ventilation Combined with Budesonide in the Treatment of Critically Ⅲ Children with Bronchiolitis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(18): 170-173.

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