药物涂层球囊联合利伐沙班在冠状动脉分叉病变边支介入治疗中的应用

摘要/Abstract

摘要： 目的分析药物涂层球囊联合利伐沙班在冠状动脉分叉病变边支介入治疗中的应用效果。方法选取2020年10月—2022年10月宁德师范学院附属宁德市医院收治的68例冠状动脉分叉病变患者进行研究,应用随机数表方法分为对照组与观察组,各34例。两组患者行双导丝边支介入治疗期间,对照组应用利伐沙班治疗,观察组应用药物涂层球囊联合利伐沙班治疗,比较两组临床治疗效果。结果观察组患者不良心血管事件发生率低于对照组,差异有统计学意义（P<0.05）;观察组患者的边支狭窄率、边支闭塞率低于对照组,差异有统计学意义（P<0.05）;观察组患者血管性血友病因子（Von Willebrand Factor,vWF）、血管紧张素Ⅱ（Angiotensin Ⅱ,AngⅡ）、超敏C反应蛋白（High Sensitive C-Reactive Protein,hs-CRP）、糖化血红蛋白A_1c（Hemoglobin A_1c,HbA_1c）水平均低于对照组,差异有统计学意义（P<0.05）;观察组患者躯体健康评分、心理健康评分高于对照组,差异有统计学意义（P<0.05）。结论药物涂层球囊联合利伐沙班在冠状动脉分叉病变边支介入治疗中的应用效果良好,可有效减少患者的不良心血管事件发生,改善临床疗效,降低术后边支狭窄率与边支闭塞率,提升患者生活质量,发挥积极应用价值。

关键词: 利伐沙班, 冠状动脉分叉病变, 药物涂层球囊, 介入治疗

Abstract: Objective To analyze the clinical effect of drug coated balloon combined with Rivaroxaban in the treatment of coronary bifurcation lesions. Methods A total of 68 patients with coronary bifurcation lesions in Ningde City Hospital affiliated to Ningde Normal University from October 2020 and October 2022 were selected for the study, they were randomly divided into a control group and an observation group using a random number table method, and 34 cases in each group. During the interventional therapy of both groups, the control group applied Rivaroxaban treatment, and the observation group used drug-coated balloon combined with Rivaroxaban treatment to compare the clinical treatment effect of the two groups. Results The incidence of adverse cardiovascular events in the observation group was lower than that in the control group, with significant differences between the two groups (P<0.05). The side branch stenosis rate and side branch occlusion rate of the observation group patients were lower than those of the control group, and the difference was statistically significant (P<0.05). The vWF, Ang II, hsCRP, and HbA_lc levels in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). The physical and mental health scores of the observation group patients were higher than the control group, and the difference was statistically significant (P<0.05). Conclusion drug coated balloon combined with Rivaroxaban in the treatment of coronary bifurcation lesions has good effect, it can effectively reduce the incidence of adverse cardiovascular events, improve the clinical efficacy, reduce the rate of postoperative stenosis and edge occlusion, improve the quality of life of patients, play a positive application value.

Key words: Rivaroxaban, coronary artery bifurcation lesions, drug coated balloon, interventional therapy

中图分类号:

R541.4

刘国兴. 药物涂层球囊联合利伐沙班在冠状动脉分叉病变边支介入治疗中的应用[J]. 中华养生保健, 2024, 42(17): 53-56.

LIU Guo-xing. Application of Drug Coated Balloon Combined with Rivaroxaban in the Treatment of Coronary Bifurcation Lesions[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(17): 53-56.

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