加味五虎汤联合布地奈德混悬液对小儿咳嗽变异性哮喘的疗效研究

中华养生保健 ›› 2024, Vol. 42 ›› Issue (16): 25-27.

加味五虎汤联合布地奈德混悬液对小儿咳嗽变异性哮喘的疗效研究

张慕儿¹, 朱素娟², 林睿爽³, 郭岱年^2,*

1.汕头市中医医院中药房,广东汕头,515041;
2.汕头大学医学院附属肿瘤医院药物临床试验机构,广东汕头,515041;
3.汕头大学医学院附属肿瘤医院中医科,广东汕头,515041

出版日期:2024-08-16 发布日期:2024-08-13
通讯作者: ^*郭岱年,E-mail：guodainian@163.com。
作者简介:张慕儿（1988—）,女,汉族,籍贯：广东省汕头市,本科,主管中药师,研究方向：中药、中药制剂。

Study on the Therapeutic Effect of Modified Wuhu Decoction Combined with Budesonide Suspension in Paediatric Cough Variant Asthma

ZHANG Mu-er¹, ZHU Su-juan², LIN Rui-shuang³, GUO Dai-nian^2,*

1. Pharmacy of TCM, Shantou Hospital of TCM, Shantou GuangDong 515041, China;
2. Drug Clinical Trial Institute, Cancer Hospital Affiliated to Shantou University Medical College, Shantou GuangDong 515041, China;
3. Department of Traditional Chinese Medicine, Cancer Hospital Affiliated to Shantou University Medical College, Shantou GuangDong 515041, China

Online:2024-08-16 Published:2024-08-13

摘要/Abstract

摘要： 目的研究加味五虎汤联合布地奈德混悬液治疗小儿咳嗽变异性哮喘的疗效。方法选择2020年1月—2022年12月汕头市中医医院收治的96例咳嗽变异性哮喘患儿作为研究对象,取随机数表法分将其为对照组和观察组,各48例。对照组采用布地奈德混悬液治疗,观察组在对照组治疗基础上联用加味五虎汤治疗。评估两组患者的症状,检测两组患者的用力呼气量占用力肺活量比值（FEV₁/FVC）、最大通气量表（MVV）、最大呼气中期流速（MMF）和呼气峰流速（PEF）,且检测两组患者的血清白细胞介素-5（IL-5）、基质金属蛋白酶-9（MMP-9）、嗜酸性粒细胞阳离子蛋白（ECP）和IL-8水平。结果治疗后,两组的咳嗽、鼻涕、咽痒、气促、喷嚏和鼻塞症状积分均明显降低,且观察组明显低于对照组,差异有统计学意义（P<0.05）;治疗后,两组的FEV₁/FVC、MVV、MMF和PEF均明显改善,且观察组明显优于对照组,差异有统计学意义（P<0.05）;治疗后,两组的血清IL-5、MMP-9、ECP和IL-8水平均明显降低,且观察组明显低于对照组,差异有统计学意义（P<0.05）。结论加味五虎汤联合布地奈德混悬液治疗小儿咳嗽变异性哮喘的疗效显著,能明显改善肺功能和减轻症状,其机制可能与降低血清IL-5、MMP-9、ECP和IL-8水平有关。

关键词: 加味五虎汤, 布地奈德混悬液, 咳嗽变异性哮喘

Abstract: Objective To investigate the effect ofmodified Wuhu decoction combined with Budesonide suspension on cough variant asthma in children. Methods Selected 96 cases of patients with cough variant asthma admitted to Shantou Hospital of Traditional Chinese Medicine from January 2020 to December 2022, divided into two groups by taking the randomized numerical table method. The control group was treated with Budesonide suspension, and the observation group was treated with modified Wuhu Decoction.The symptoms of the two groups were evaluated, and the forced expiratory volume to forced Vital capacity ratio (FEV₁/FVC), maximum ventilation volume scale (MVV), maximum middle expiratory flow (MMF) and peak expiratory flow (PEF) were measured, and the levels of serum interleukin-5 (IL-5), matrix metalloproteinase-9 (MMP-9), Eosinophil cationic protein (ECP) and IL-8 were measured. Results After treatment, the scores of cough, nasal discharge, throat itching, shortness of breath, sneezing and nasal congestion in both groups were significantly decreased (P<0.05), and the observation group was significantly lower than the control group (P<0.05). After treatment, FEV₁/FVC, MVV, MMF and PEF in both groups were significantly improved (P<0.05), and the observation group was significantly better than the control group (P<0.05). After treatment, the serum levels of IL-5, MMP-9, ECP and IL-8 in both groups were significantly decreased (P<0.05), and the observation group was significantly lower than the control group (P<0.05). Conclusion Jiawei Wuhu Decoction combined with Budesonide suspension has a significant effect on cough variant asthma in children, which can significantly improve lung function and relieve symptoms. Its mechanism may be related to the reduction of serum IL-5, MMP-9, ECP and IL-8 levels, which is worth promoting.

Key words: Flavored Five Tiger Soup, budesonide suspension, cough variant asthma

中图分类号:

R287

张慕儿, 朱素娟, 林睿爽, 郭岱年. 加味五虎汤联合布地奈德混悬液对小儿咳嗽变异性哮喘的疗效研究[J]. 中华养生保健, 2024, 42(16): 25-27.

ZHANG Mu-er, ZHU Su-juan, LIN Rui-shuang, GUO Dai-nian. Study on the Therapeutic Effect of Modified Wuhu Decoction Combined with Budesonide Suspension in Paediatric Cough Variant Asthma[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(16): 25-27.

参考文献

[1] 白英杰,郭凯,黄姗姗,等.祛风宁肺散联合孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床疗效及其对免疫功能的影响[J].川北医学院学报,2021,36(6):737-740.
[2] 周炳文,王莎莎,颜世军.三药联合治疗对咳嗽变异性哮喘患儿免疫功能和气道炎症因子水平及肺功能的影响[J].中国医药,2022,17(2):200-204.
[3] 宋英,李雪茹,郭传振,等.氨溴特罗口服液联合布地奈德混悬液治疗咳嗽变异性哮喘患儿的疗效及对血清IgE,EOS,炎症因子的影响[J].内蒙古医学院学报,2021,43(4):369-371.
[4] 中华医学会儿科学分会呼吸学组慢性咳嗽协作组,编辑委员会中华儿科杂志.中国儿童慢性咳嗽诊断与治疗指南(2013年修订)[J].中华儿科杂志,2014,52(3):184-188.
[5] 汪受传,虞坚尔.中医儿科学[M].3版.北京:中国中医药出版社,2012:79.
[6] 王焜,岳喜峰,阳练.降气平喘针法联合电针治疗咳嗽变异性哮喘的疗效及对血清EOS,IgE和TNF-α水平影响[J].针灸临床杂志,2021,37(7):40-43.
[7] 吕从改,张瑾,孙明宇.疏风益气汤联合沙美特罗替卡松治疗咳嗽变异性哮喘疗效研究及对肺功能,气道炎症反应及复发率的影响[J].天津中医药,2021,38(10):1263-1267.
[8] 刘威威,苏玉峰,王欢,等.不同疗程布地奈德福莫特罗对咳嗽变异性哮喘患者疗效及辅助性T细胞因子的影响研究[J].实用心脑肺血管病杂志,2021,29(7):115-120.
[9] 乔巧,徐晓丽,刘军,等.健脾保肺滋肾推拿法对小儿咳嗽变异性哮喘疗效,炎性因子及免疫功能的影响[J].吉林中医药,2022,42(4):439-442.
[10] 张宁宁,吴力群.基于脾胃学说分期论治小儿咳嗽变异性哮喘[J].世界中医药,2022,17(19):2772-2775.
[11] 刘芳,杨雪,张肖瑾.加味五虎汤联合孟鲁司特钠治疗儿童咳嗽变异性哮喘临床观察[J].陕西中医,2021,42(5):612-615.
[12] 董秀兰,许华,张雪丽,等.加味五虎汤对小儿支原体肺炎临床疗效及T细胞亚群的影响[J].世界中医药,2021,16(3):458-466.
[13] 王洁,王丹丹,潘永,等.嗜酸性粒细胞,白细胞介素-23/Th17轴及小气道功能与小儿咳嗽变异性哮喘的相关性分析[J].安徽医药,2021,25(3):537-540.
[14] 李明,李伟元,黎俊玲.小儿推拿联合止敏平喘汤对咳嗽变异性哮喘患儿肺功能,免疫功能及外周EOS,ECP,IL-5的影响[J].长春中医药大学学报,2022,38(8):893-896.
[15] 张宁宁,霍婧伟,朱珂,等.加味六安煎对咳嗽变异性哮喘大鼠MMP-9及TIMP-1水平的影响[J].中华中医药杂志,2021,36(5):2912-2914.
[16] 李莎,舒秀兰.小儿肺热咳喘颗粒联合丙酸氟替卡松治疗小儿支气管哮喘疗效及对IL-6,IL-8及TNF-α水平的影响[J].中华中医药学刊,2021,39(3):237-240.
[17] 胡燕,荀春铮,丁伊.加味五虎汤对痰热壅肺型咳嗽变异性哮喘患儿血清炎性因子和免疫球蛋白的影响[J].中医药导报,2021,27(3):96-103.