凝血酶联合质子泵抑制剂治疗上消化道出血的疗效观察

摘要/Abstract

摘要： 目的观察凝血酶联合质子泵抑制剂治疗上消化道出血的疗效。方法将2020年1月—2023年1月固原市原州区人民医院收治的320例上消化道出血患者作为研究对象,按照随机数表法分为对照组和观察组,每组160例。对照组采取质子泵抑制剂（奥美拉唑注射液）治疗,观察组在此基础上增加凝血酶治疗。比较两组止血情况（止血时间、输血量、再出血率、住院时间）、格拉斯哥-布拉奇福德出血评分（GBS）情况,治疗有效率及不良反应发生率。结果观察组止血时间、输血量、再出血率及住院时间均少于对照组,差异有统计学意义（P<0.05）。治疗前,两组GBS评分比较,差异无统计学意义（P>0.05）;治疗后,两组GBS评分均下降,观察组评分低于对照组,差异有统计学意义（P<0.05）。观察组治疗有效率高于对照组,差异有统计学意义（P<0.05）。两组不良反应发生率比较,差异无统计学意义（P>0.05）。结论凝血酶联合质子泵抑制剂治疗上消化道出血疗效显著,能够提高止血效率,缓解出血危急程度,并且不会增加不良反应,值得临床使用。

关键词: 凝血酶, 质子泵抑制剂, 上消化道出血, 止血情况, GBS

Abstract: Objective To observe the curative effect of thrombin combined with proton pump inhibitor on upper gastrointestinal bleeding. Methods A total of 320 patients with upper gastrointestinal bleeding admitted to our hospital from January 2020 to January 2023 were randomly divided into control group and observation group, with 160 patients in each group. The control group was treated with proton pump inhibitor (omeprazole injection), while the observation group was treated with thrombin on the basis of this. Hemostasis (hemostasis time, blood transfusion, rebleeding rate, hospitalization time), Glasgow-Blatchford bleeding score (GBS), treatment efficiency and adverse reactions were compared between the two groups. Results The hemostatic time, blood transfusion volume, rebleeding rate and hospitalization time in the observation group were lower than those in the control group, with statistical significance (P<0.05).Before treatment, there was no significant difference in GBS scores between the two groups (P>0.05). After treatment, the GBS scores of the two groups decreased, and the scores of the observation group were lower than those of the control group, with significant difference (P<0.05).The effective rate in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05).There was no significant difference in the adverse reaction rate between the observation group and the control group (P>0.05). Conclusion Thrombin combined with proton pump inhibitor is effective in the treatment of upper gastrointestinal bleeding, which can improve the hemostasis efficiency and relieve the critical degree of bleeding, and will not increase the adverse reactions, so it has the significance of popularization and use.

Key words: thrombin, proton pump inhibitor, upper gastrointestinal bleeding, hemostasis, GBS

中图分类号:

R573.2

宋丽凤, 宋丽君. 凝血酶联合质子泵抑制剂治疗上消化道出血的疗效观察[J]. 中华养生保健, 2024, 42(16): 169-171.

SONG Li-feng, SONG Li-jun. Observation on Therapeutic Effect of Thrombin Combined with Proton Pump Inhibitor on Upper Gastrointestinal Bleeding[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(16): 169-171.

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