慢性肾衰患者血清甲状腺激素水平与eGFR的相关性

摘要/Abstract

摘要： 目的探讨与分析慢性肾衰患者血清甲状腺激素水平与肾小球滤过率（glomerular filtration rate,eGFR）的相关性。方法选取2020年2月—2022年7月于贵州航天医院肾脏风湿科进行诊治的50例慢性肾衰患者作为慢性肾衰组,并选取同期到贵州航天医院体检的42名正常人群作为对照组,检测慢性肾衰组与对照组患者的血清总甲状腺素（total thyroxine,TT4）、血清总三碘甲状腺原氨酸（total triiodothyronine,TT3）、血清游离三碘甲状腺原氨酸（free-T3,FT3）等含量,同时测定患者的肾小球滤过率等肾功能指标并进行比较,并进行Pearson相关性分析和多因素Logistic回归分析。结果慢性肾衰组的血清TT4、TT3、FT3含量明显低于对照组（P<0.05）。慢性肾衰组的肾小球滤过率明显低于对照组（P<0.05）,血清尿素氮、血清肌酐含量也明显高于对照组（P<0.05）。在慢性肾衰组中,Pearson相关分析显示肾小球滤过率与血清TT4、TT3、FT3含量都存在相关性（P<0.05）。多因素Logistic回归分析显示血清TT4、TT3、FT3含量为影响肾小球滤过率的重要危险因素（P<0.05）。结论慢性肾衰患者多伴随有血清TT4、TT3、FT3含量降低与肾小球滤过率明显降低,血清甲状腺激素水平与肾小球滤过率存在相关性。

关键词: 慢性肾衰, 总甲状腺素, 游离三碘甲状腺原氨酸, 肾小球滤过率, 相关性

Abstract: Objective To explore and analysis the correlation between serum Thyroid hormones level and glomerular filtration rate (eGFR) in patients with chronic renal failure. Methods From February 2020 to July 2022, 50 cases of chronic renal failure patients who were diagnosed and treated in the Department of Nephrology and Rheumatology of Guizhou Aerospace Hospital were selected as the chronic renal failure group. And 42 cases of normal people who went to Guizhou Aerospace Hospital for physical examination in the same period were selected as the control group. The serum total thyroxine （TT4）, serum total triiodothyronine （TT3）, and serum free triiodothyronine （FT3） levels were detected in the two groups of patients, and the renal function indexes such as glomerular filtration rate were also determined for comparison. Pearson correlation analysis and multifactor logistic regression analysis were also performed. Results The levels of serum TT4、TT3、FT3 in the Chronic renal failure group were significantly lower than those in the control group (P<0.05). The glomerular filtration rate in the Chronic renal failure group were significantly lower than that in the control group (P<0.05), and the content of serum Blood urea nitrogen and serum creatinine were also significantly higher than that in the control group (P<0.05). In the Chronic renal failure group, Pearson correlation analysis showed that glomerular filtration rate were correlated with serum TT4、TT3、FT3 (P<0.05). Multivariate logistic regression analysis showed that serum TT4、TT3、FT3 were important risk factors affecting glomerular filtration rate (P<0.05). Conclusion The patients with chronic renal failure are mostly accompanied by the decrease of serum TT4、TT3、FT3 and the glomerular filtration rate. The serum Thyroid hormones level is correlated with the glomerular filtration rate.

Key words: chronic renal failure, total thyroxine, free triiodothyronine, glomerular filtration rate, relativity

中图分类号:

R692

谢谋进. 慢性肾衰患者血清甲状腺激素水平与eGFR的相关性[J]. 中华养生保健, 2024, 42(15): 54-57.

XIE Mou-jin. Correlation Between Serum Thyroid Hormones Level and eGFR in Patients with Chronic Renal Failure[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(15): 54-57.

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